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Diss Factsheets
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EC number: 224-030-0 | CAS number: 4170-30-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral LD50 rats: 174 mg/kg
Acute dermal LD50 in guinea pigs: 26 mg/kg
Acute inhalation LC50 in rats (4 hour): 120 ppm (336 mg/m3)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 174 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 336 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 26 mg/kg bw
Additional information
For acute oral toxicity in rats best data available (Union Carbide, 1942) was chosen and the oral LD50 for male and female rats upon oral gavage = 174 mg/kg.
For acute dermal toxicity, only data in guinea pigs is available (Smyth and Carpenter, 1944). Available data demonstrates that crotonaldehde is toxic upon dermal application (2 -24 hour application). Good agreement in available studies for 4 day exposure to crotonaldehyde (c.a. 25 mg/kg and 30 mg/kg from different publications). The dermal application of crotonaldehyde to guinea pig resulted in an LD50 of 26 mg/kg. No reliable data was identified in other species.
For acute inhalation toxicity, the best available data is Rinehart (1967). The study provides data from 10 min to 4 hour exposure times in rats. There are some analytical issues (difference between analytical and nominal values) but the data and dose response are consistent. Also, studies in mouse, rat and human showed that crotonaldehyde is a strong respiratory irritant. Results suggest that rat is the most sentitive species. LC50 value for 4 hour of exposure (within 24 hr) was 120 ppm (336 mg/m3), nevertheless, a ceiling threshold level value has been established at 0.3 ppm (0.86 mg/m3) for occupational exposure to minimize the potential for rapid irritation to the respiratory tract (and eyes).
Justification for classification or non-classification
According to criteria in Regulation (EC) No. 1272/2008, as well as requirements in Annex VI thereof, and based on the observed LD50 values (acute oral, dermal and inhalation), the susbtance has to be classified as follows:
Oral - acute toxicity Cat 3
Dermal - acute toxicity Cat 1
Inhalation - acute toxicity Cat 2
STOT - single exposure Cat 3
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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