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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: not according to current protocols, limited documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Principles of method if other than guideline:
according to Smyth, H.F. et al.: Am. Ind. Hyg. Assoc. J. 23, 95-107 (1962)
GLP compliance:
no
Test type:
other: inhalation hazard test

Test material

Constituent 1
Chemical structure
Reference substance name:
(R*,R*)-α,4-dimethyl-α-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol
EC Number:
208-205-9
EC Name:
(R*,R*)-α,4-dimethyl-α-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol
Cas Number:
515-69-5
Molecular formula:
C15H26O
IUPAC Name:
6-methyl-2-(4-methylcyclohex-3-en-1-yl)hept-5-en-2-ol
Test material form:
other: liquid
Details on test material:
Name of the test substance used in the study report: (+-)-alpha-Bisabolol

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
not specified
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Inhalation of an atmosphere enriched with volatile constituents at 20°C. For enrichment, 200 l air/h was passed through a layer of about 5 cm of the test substance.
Analytical verification of test atmosphere concentrations:
no
Remarks:
Test substance concentration has been determined by differential weighing of the test substance before and after exposure.
Duration of exposure:
7 h
Concentrations:
0.14 mg/l
No. of animals per sex per dose:
12
Control animals:
other: not applicable
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: end of exposure d1, d3, d14

Results and discussion

Mortality:
None
Clinical signs:
other: None
Gross pathology:
Sacrificed animals: nothing abnormal found in organs.

Applicant's summary and conclusion