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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: not according to current protocols, limited documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Principles of method if other than guideline:
according to Smyth, H.F. et al.: Am. Ind. Hyg. Assoc. J. 23, 95-107 (1962)
GLP compliance:
no
Test type:
other: inhalation hazard test

Test material

Constituent 1
Chemical structure
Reference substance name:
(R*,R*)-α,4-dimethyl-α-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol
EC Number:
208-205-9
EC Name:
(R*,R*)-α,4-dimethyl-α-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol
Cas Number:
515-69-5
Molecular formula:
C15H26O
IUPAC Name:
6-methyl-2-(4-methylcyclohex-3-en-1-yl)hept-5-en-2-ol
Test material form:
other: liquid
Details on test material:
Name of the test substance used in the study report: (+-)-alpha-Bisabolol

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
not specified
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Inhalation of an atmosphere enriched with volatile constituents at 20°C. For enrichment, 200 l air/h was passed through a layer of about 5 cm of the test substance.
Analytical verification of test atmosphere concentrations:
no
Remarks:
Test substance concentration has been determined by differential weighing of the test substance before and after exposure.
Duration of exposure:
7 h
Concentrations:
0.14 mg/l
No. of animals per sex per dose:
12
Control animals:
other: not applicable
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: end of exposure d1, d3, d14

Results and discussion

Mortality:
None
Clinical signs:
other: None
Gross pathology:
Sacrificed animals: nothing abnormal found in organs.

Applicant's summary and conclusion

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