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Particle size distribution (Granulometry)

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Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Non-GLP, guideline study, well reported, reliable without restrictions
Qualifier:
according to
Guideline:
DIN 55992-1 (Determination of a parameter for the dust formation of pigments and extenders - Part 1: Rotation method)
Deviations:
no
GLP compliance:
no
Type of method:
rotating drum method
Remarks:
modified Heubach procedure
Type of particle tested:
other: dust particles
Type of distribution:
mass based distribution
Mass median aerodynamic diameter:
28.96 µm
Geometric standard deviation:
2.3

Experimental results

Quantity of substance used [g]: 1

Total dust mass in impactor [mg]: 237.16

Dust concentration in impactor [mg/m³]: 1181.74

Total dustiness [mg/g]: 237.16

Inhalable fraction [mg/g]: 147.63

Thoracic fraction [mg/g]: 44.65

Respirable fraction [mg/g]: 7.98

Mass Median Aerodynamic Diameter (MMAD) = 28.96 μm (GSD = 2.30 μm)

Conclusions:
The total dustiness of Diammonium sodium hexakis( nitrito-N)rhodate was determined to be 237.16 mg/g. The inhalable fraction was 147.63 mg/g, the thoracic fraction was 44.65 mg/g and the respirable fraction was 7.98 mg/g. The Mass Median Aerodynamic Diameter (MMAD) was 28.96 μm with Geometric Standard Deviation of 2.3 μm.
Executive summary:

The dustiness of Diammonium sodium hexakis( nitrito-N)rhodate was tested in a modified Heubach procedure according to the guideline DIN 55992-1:2006 'Determination of a parameter for the dust formation of pigments and extenders - Part 1: Rotation method'. The substance was mechanically stressed in a rotating drum and the airborne dust was fed into a seven-stage cascade impactor. The dust masses collected at each cascade stage were weighed to determine total dustiness. Dust from 1.00 g of sample was generated for 5 min at a temperature of 25.0 ºC, 50.5 % relative humidity and 995.0 hPa atmosphere. The dustiness values in accordance with DIN EN 481 were calculated from the particle size distribution determined (cumulative frequency distribution) with the help of an excel macro. The study is non-GLP, but follows a standard guideline and is considered to be reliable. The total dustiness of Diammonium sodium hexakis( nitrito-N)rhodate was determined to be 237.16 mg/g. The inhalable fraction was 147.63 mg/g, the thoracic fraction was 44.65 mg/g and the respirable fraction was 7.98 mg/g. The Mass Median Aerodynamic Diameter (MMAD) was 28.96 μm with Geometric Standard Deviation of 2.3 μm.

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
Version / remarks:
Screening Test
GLP compliance:
yes (incl. certificate)
Type of method:
sieving
Type of particle tested:
primary particle
Type of distribution:
mass based distribution
No.:
#1
Size:
< 100 µm
Distribution:
0.696 %
Remarks on result:
other:
Remarks:
The proportion of test item < 100 µm was 0.696 %.

The results of the sieving procedure are shown below:

 Measurement

Result 

Mass of test item transferred to sieve 

10.06g

 Mass of test item passed through sieve

0.070g

Proportion of test item <100µm 

0.696%
Conclusions:
The proportion of diammonium sodium hexakis (nitrito-N)rhodate <100 μm was 0.696 %.
Executive summary:

Atwal and Tremain (2011) is a GLP compliant study following OECD 110 (screening method) and is considered suitable for use as the key study for this endpoint.

The proportion of diammonium sodium hexakis (nitrito-N)rhodate < 100 μm is 0.696 %.

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March - June 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
according to
Guideline:
other: ISO 9277:2010(E)
Qualifier:
according to
Guideline:
other: AA_LP_814_BET_08
Qualifier:
according to
Guideline:
other: ISO 14488:2007(E)
Qualifier:
according to
Guideline:
other: ISO 13320:2009(E)
Qualifier:
according to
Guideline:
other: SAA_Troken_DISP, SAA LB2000
Principles of method if other than guideline:
The material was analysed for particle size distribution after dry dispersion and N-BET.
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Percentile:
D10
Mean:
1.51 µm
Remarks on result:
other: Range; 1.48 - 1.55 µm
Key result
Percentile:
D50
Mean:
9.3 µm
Remarks on result:
other: Range; 9.2 - 9.5 µm
Percentile:
D90
Mean:
43 µm
Remarks on result:
other: Range; 39 - 48 µm

Specific surface area N-BET = 1.09 +/- 0.01 m2/g. Range = 1.08 +/- 0.002 to 1.10 +/- 0.002 m2/g.

Table 1: N-BET analysis data and percentiles calculated from the particle size distribution for Diammonium sodium hexakis(nitrito-N)rhodate.

   Analysis 1  Analysis 2  Analysis 3  Average
 Specific surface area N-BET (m2/g) 1.10 ± 0.002  1.08 ± 0.002   1.09 ± 0.01
 X10;3 (μm)  1.48 1.55  1.51  1.51
 X50;3 (μm)  9.2  9.5  9.3  9.3
 X90;3 (μm)  43  48  39  43
Conclusions:
The average 10th, 50th and 90th percentile particle sizes for Diammonium sodium hexakis(nitrito-N)rhodate were 1.51, 9.3 and 43 μm, respectively. The specific surface area was determined as 1.09 ± 0.01 m2/g.
Executive summary:

This is a non-GLP experimental study that follows standard test guidelines and is suitable for use for assessing this endpoint. The material was analysed for particle size distribution after dry dispersion and N-BET. The average 10th, 50th and 90th percentile particle sizes for Diammonium sodium hexakis(nitrito-N)rhodate were 1.51, 9.3 and 43 μm, respectively. The specific surface area was determined as 1.09 ± 0.01 m2/g.

Description of key information

Two samples of diammonium sodium hexakis(nitrito-N)rhodate were tested, the first in a screening test and the second for particle size analysis and specific surface area.

In the screening test, the proportion of diammonium sodium hexakis (nitrito-N)rhodate < 100 μm was 0.696 %.

The particle size analysis determined the average 10th, 50th and 90th percentile particle sizes for diammonium sodium hexakis(nitrito-N)rhodate were 1.51, 9.3 and 43 μm, respectively. The specific surface area was determined as 1.09 ± 0.01 m2/g.

Additional information

Atwal and Tremain (2011) is a GLP compliant study following OECD 110 (screening method) and is considered suitable for use as the key study for this endpoint. For the sample tested, the proportion of diammonium sodium hexakis (nitrito-N)rhodate < 100 µm was 0.696 %.

 

Pothoff (2012) is a non-GLP experimental study that follows standard test guidelines and is also suitable for use as a key study for assessing this endpoint. The sample was analysed for particle size distribution after dry dispersion and N-BET. The average 10th, 50th and 90th percentile particle sizes for diammonium sodium hexakis(nitrito-N)rhodate were 1.51, 9.3 and 43 µm, respectively. The specific surface area was determined as 1.09 ± 0.01 m2/g.

 

The dustiness of diammonium sodium hexakis( nitrito-N)rhodate was tested in a modified Heubach procedure according to the guideline DIN 55992-1:2006. The study is non-GLP, but follows a standard guideline and is considered to be reliable. The total dustiness of diammonium sodium hexakis(nitrito-N)rhodate was determined to be 237.16 mg/g. The inhalable fraction was 147.63 mg/g, the thoracic fraction was 44.65 mg/g and the respirable fraction was 7.98 mg/g. The Mass Median Aerodynamic Diameter (MMAD) was 28.96 µm with Geometric Standard Deviation of 2.3 µm.