Registration Dossier
Registration Dossier
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EC number: 228-937-2 | CAS number: 6375-46-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from journal of C R C Critical Reviews in Environmental Control.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Current status of human safety and environmental aspects of fluorescent whitening agents used in detergents in the United States
- Author:
- Alan W. Burg, Michael W. Rohovsky, Charles J. Kensler, Arthur D. Little, Inc., Cambridge, Massachusetts
- Year:
- 1 977
- Bibliographic source:
- C R C Critical Reviews in Environmental Control, 7:1, 91-120, 1977.
- Reference Type:
- other: Authoritative database
- Title:
- RTECS Number : WJ6127000
- Author:
- RTECS database
- Year:
- 2 017
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); CCECAU Criticial Reviews in Environmental Control. (Chemical Rubber Company, Cleveland, OH) V.1- 1970- Volume(issue)/page/year: 7,91,1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: refer below
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of Disodium 4,4'-bis[[6-anilino-4-[(2-hydroxyethyl)methylamino]-1,3,5 -triazin-2-yl]amino] stilbene-2,2'-disulphonate (CAS No. 13863-31-5) in rat by the oral route.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Disodium 4,4'-bis[[6-anilino-4-[(2-hydroxyethyl)methylamino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate
- EC Number:
- 237-600-9
- EC Name:
- Disodium 4,4'-bis[[6-anilino-4-[(2-hydroxyethyl)methylamino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate
- Cas Number:
- 13863-31-5
- Molecular formula:
- C38H40N12O8S2.2Na
- IUPAC Name:
- Disodium 4,4'-bis[[6-anilino-4-[(2-hydroxyethyl)methylamino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- No data available
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality observed
- Mortality:
- 50% mortality observed
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified based on CLP criteria
- Conclusions:
- The acute oral median lethal dose (LD50) of Disodium 4,4'-bis[[6-anilino-4-[(2-hydroxyethyl)methylamino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate in rat was observed to be >10,000 mg/kg b.wt.
- Executive summary:
The acute toxicity study was conducted to evaluate the toxic effects of administration of Disodium 4,4'-bis[[6-anilino-4-[(2-hydroxyethyl)methylamino]-1,3,5 -triazin-2-yl]amino]stilbene-2,2'-disulphonate (CAS No. 13863-31-5) in rat by the oral route. 50% mortality was observed. The acute oral median lethal dose (LD50) of Disodium 4,4'-bis[[6-anilino-4-[(2-hydroxyethyl)methylamino]-1,3,5-triazin-2-yl]amino] stilbene-2,2'-disulphonate in rat was observed to be >10000 mg/kg b.wt. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Disodium 4,4'-bis[[6-anilino-4-[(2-hydroxyethyl)methyl amino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate (CAS No. 13863-31-5) does not exhibit acute toxicity via the oral route.
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