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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Carcinogenicity

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Administrative data

Description of key information

Three studies were performed to examine the carcinogenic potential of the test substance by different routes of administration. None of the studies was GLP or OECD guideline conform. Due to very low dose levels or non relevant routes of exposure the three studies are considered as unsuitable for evaluation.

Key value for chemical safety assessment

Justification for classification or non-classification

These data from secondary sources are not suiteable to derive or to change the current classification and labelling of the substance according the dangerous substance directive (67/548/EEC) or theClassification, Labeling, and Packaging Regulation (EC) No. 1272/2008.

Additional information

Three studies with regard to the possible carcinogenicity of o-aminophenol have been submitted. In the first study published in 1948, the sensitivity is considered too low to draw any conclusion. The second study involved implantation of pellets containing o-aminophenol in the urinary bladder of mice and is not considered relevant. The third study involved topical application of a hair dye formulation containing o-aminophenol. Since in a parallel study containing more than 10 times higher concentrations of 2,4-diaminoanisol (classified as carcinogen category 2 in EU) no tumours were found, the sensitivity of the study is considered too low for the evaluation of the carcinogenicity of o-aminophenol.