2-aminophenol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

no detailed reporting of body weight, no purity for test material

GLP compliance:

no

Test type:

fixed dose procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-aminophenol

EC Number:

202-431-1

EC Name:

2-aminophenol

Cas Number:

95-55-6

Molecular formula:

C6H7NO

IUPAC Name:

2-aminophenol

Test material form:

solid

Specific details on test material used for the study:

Supplier Hans Schwarzkopf GmbH

Test animals

Species:

rat

Strain:

other: CFY

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Anglia Laboratory Animals, Huntington, England
- Weight at study initiation: males 100 - 155g; females 90 - 115 g
- Fasting period before study: 16h
- Housing: 5 animals per cage
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/-1
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 40%

Doses:

1000, 1600, 2500, 4000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

2 500 mg/kg bw

Based on:

test mat.

Mortality:

1000 mg/kg bw: one male
1600 mg/kg bw: one male and one female
2500 mg/kg bw: three males and one female
5000 mg/kg bw: four males and five females

Clinical signs:

other: All dose groups showed curved body position, piloerection, increased breathing rate. There was dose-dependent ataxia and lethargy, paleness of extremities, tremor. Urine was coloured orange-red.

Gross pathology:

Hyperemia of liver and lung, partly also of duodenum