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EC number: 701-116-0 | CAS number: -
Viability / Mortality:
No deaths occurred during the study period.
No signs of systemic toxicity were observed during the study period. On application day 2 and 3, the animals treated with test item concentrations of 5 and 10% showed an erythema of the ear skin (Score 1). On day 4, only the animals of the high dose group showed an erythema of the ear skin (Score 1).
The body weight of the animals, recorded prior to the first application and prior to treatment with ³HTdR, was within the range commonly recorded for animals of this strain and age.
Lymph Node Weights and Cell Counts:
The measured lymph node weights and –cell counts of all animals treated were recorded after sacrifice. A statistically significant and biologically relevant increase in lymph node weight and –cell count was obtained in all test item treated groups in comparison to the
vehicle control group (p<0.05) and a clear dose response was observed. Furthermore, the cutoff-value for a positive response regarding the lymph node cell count index of 1.55 reported for BALB/c mice was exceeded in all dose groups (indices of 2.08, 3.55, and 4.94).
The measured ear weights of all animals treated were recorded after sacrifice. A statistically significant increase in ear weights was observed in the high dose group in comparison to the vehicle control group (p<0.05). Furthermore, for BALB/c mice, a cutoffvalue
of 1.1 was reported for a positive response of the ear weight index regarding ear skin irritation. None of the indices determined for the test item treated groups exceeded this threshold.
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