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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Reference
Reference Type:
other: Authoritative database
Title:
Skin sensitization study of 4-nitrobenzene-1,3-diamine in Guinea pig
Author:
IFA (GESTIS)
Year:
2011
Bibliographic source:
GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
To evaluate the skin sensitizing potential of 4-nitrobenzene-1,3-diamine in Guinea pig.
GLP compliance:
not specified
Type of study:
other: Not specified.
Justification for non-LLNA method:
Not specified.

Test material

Constituent 1
Chemical structure
Reference substance name:
4-nitro-m-phenylenediamine
EC Number:
225-876-3
EC Name:
4-nitro-m-phenylenediamine
Cas Number:
5131-58-8
Molecular formula:
C6H7N3O2
IUPAC Name:
4-nitro-m-phenylenediamine
Test material form:
solid
Details on test material:
- Name of test material : 4-Nitro-m-phenylenediamine
- Molecular formula : C6H7N3O2
- Molecular weight : 153.14 g/mol
- Smiles notation : c1(c(cc(N)cc1)N)[N+](=O)[O-]
- InChl (if other than submission substance): 1S/C6H7N3O2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H,7-8H2
- Substance type: Organic
- Physical state: Solid
Specific details on test material used for the study:
- Name of test material : 4-Nitro-m-phenylenediamine
- Molecular formula : C6H7N3O2
- Molecular weight : 153.14 g/mol
- Smiles notation : c1(c(cc(N)cc1)N)[N+](=O)[O-]
- InChl (if other than submission substance): 1S/C6H7N3O2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H,7-8H2
- Substance type: Organic
- Physical state: Solid

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available.

Study design: in vivo (non-LLNA)

Induction
Route:
other: No data available.
Challenge
Route:
other: No data available.
No. of animals per dose:
No data available.
Details on study design:
No data available.
Challenge controls:
No data available.
Positive control substance(s):
not specified

Study design: in vivo (LLNA)

Statistics:
No data available.

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Clinical observations:
Sensitization effects were observed.
Remarks on result:
positive indication of skin sensitisation

Any other information on results incl. tables

A test on the skin-sensitizing effects of the substance on guinea pigs yielded positive results and confirmed a moderate allergic potential

Applicant's summary and conclusion

Interpretation of results:
other: Sensitizing
Conclusions:
4-nitrobenzene-1,3-diamine( 5131-58-8) was observed for its skin sensitizing potential in guinea pig. The test material 4-nitrobenzene-1, 3-diamine was considered to non sensitizing in Guinea pig.
Executive summary:

4-nitrobenzene-1,3-diamine( 5131-58-8) was assessed for its possible contact allergenic potential. A test on the skin-sensitizing effects of the substance on guinea pigs yielded positive results and confirmed a moderate allergic potential. Therefore 4-nitrobenzene-1,3-diamine( 5131-58-8) was considered to be sensitizing in Guinea pig.