Registration Dossier
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EC number: 225-876-3 | CAS number: 5131-58-8
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment
An estimated BCF value of 3 was calculated in fish for 4-nitro-1,3-benzenediamine ,using an estimated log Kow of 0.55 and a regression-derived equation. This BCF value suggests that the potential for bioconcentration in aquatic organisms (fish) is low.
Additional information
Bioaccumulation: aquatic / sediment
Four studies including experimental data from authorative database and predicted data from validated models for bioaccumulation (BCF) endpoint of target chemical 4-nitrobenzene-1,3-diamine (Cas no. 5131-58-8) were summarized as follows:
First study for target chemical (Cas no. 5131-58 -8) which suggest an estimated BCF value of 3 was calculated in fish for 4-nitro-1,3-benzenediamine ,using an estimated log Kow of 0.55 and a regression-derived equation. This BCF value suggests that the potential for bioconcentration in aquatic organisms (fish) is low. (HSDB database by US EPA; 2017)
Above result is supported by prediction using BCFBAF (v3.00) model and PBT profiler which indicate the estimated bio concentration factor (BCF) for 4-nitro-1,3-benzenediamine is 3.2 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that 4-nitro-1,3-benzenediamine is not expected to bio accumulate in the aquatic environment.
Above prediction is further assisted by Scifinder database which suggest the Bioconcentration factor (BCF) for target chemical 4-nitrobenzene-1,3-diamine was estimated to be 1.0 at pH 1, 1.68 at pH 2, 1.85-1.88 at pH range 3-10 at temperature 25 deg.C.Based on the BCF concentration at all range of pH it is concluded that the test chemical 4-nitrobenzene-1,3-diamine is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
Chemspider - ACD/PhysChem Suite prediction model indicate the Bioconcentration factor (BCF) for target chemical 4-nitrobenzene-1,3-diamine was estimated to be 5.10 at pH 5.5 and 7.4 at temperature 25 deg.C. Based on the BCF concentration at two different pH concluded that the test chemical 4-nitrobenzene-1,3-diamine is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
Thus based on all available studies for bioaccumulation endpoint concluded that the test substance 4-nitrobenzene-1,3-diamine (Cas no. 5131-58-8) is expected to be non Bioaccumulative in aquatic environment.
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