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Diss Factsheets

Physical & Chemical properties

Density

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Reference
Endpoint:
density
Remarks:
density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-02-16 – 2017-02-16
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental result performed using standard methods of analysis
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Principles of method if other than guideline:
The density is calculated from the difference in weight between the full and empty pycnometer and its volume
GLP compliance:
no
Type of method:
pycnometer method
Specific details on test material used for the study:
- Name of test material (as cited in study report):2-Bromoethylamine hydrobromide
- Molecular formula :C2H6BrNBrH
- Molecular weight: 204.892 g/mol
- Substance type:Organic
- Physical state:Solid
Key result
Type:
pour density
Density:
0.978 g/cm³
Temp.:
28.3 °C
Key result
Type:
tap density
Density:
1.18 g/cm³
Temp.:
28.3 °C

Method Details

Observations

Guideline

OECD 109

1stReading

2ndReading

Method

Test methods: Pour density and tapped density of

powders” recommended in

The International

Pharmacopoeia, Fourth

Edition, 2014

 

 

Principle of method

Pour Density:It is the ratio of known weight of test item and its volume in graduated

glass cylinder.

Tap Density: It is the

difference between the

volume of test item

measured before & after tapping in the graduated glass cylinder.

 

 

Test temperature (°C)

 

28.1 °C

28.1 °C

Atmospheric

pressure (in hPa)

 

979.5

979.4

Weight of test

item(m)

 

20.008

20.007

Volume of measuring

cylinder; readability

in g

 

50ml ; 1 ml

50 ml; 1ml

Volume of test item

without tapping (V)

 

20

21

Volume of test item

after tapping ( V1)

After 10 tapping

16

18

 

After 50 tapping

16

18

 

After 100 tapping

 

 

 

After 250 tapping

-

-

 

After 500 tapping

-

-

 

After 750 tapping

-

-

 

CALCULATIONS:

By Pour Density and Tapped Density Method:

Parameters

Details

Calculated values

Average

Density

 

 

1st

Calculation

2nd

Calculation

 

Pour Density of test Item

(g/cm³)

m/v

20.008/20

=1.004

20.009/21

=0.9528

0.9784

Tap density of test Item

(g/cm³)

m/v

20.008/16

=1.250

20.009/18

=1.111

1.180

 

Conclusions:
The density of substance 2-bromoethylammonium bromide (CAS No. 2576-47-8)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of test item was determined to be 0.9784 g/cm³ and 1.180 g/cm³at 28.3°C and 979.4 hPa.
Executive summary:

The density of substance 2-bromoethylammonium bromide (CAS No. 2576-47-8)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of test item was determined to be 0.9784 g/cm³ and 1.180 g/cm³at 28.3°C and 979.4 hPa.

Description of key information

The density of substance 2-bromoethylammonium bromide (CAS No. 2576-47-8)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of test item was determined to be 0.9784 g/cm³ and 1.180 g/cm³at 28.3°C and 979.4 hPa.

Key value for chemical safety assessment

Relative density at 20C:
0.978

Additional information

The density of substance 2-bromoethylammonium bromide (CAS No. 2576-47-8)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of test item was determined to be 0.9784 g/cm³ and 1.180 g/cm³at 28.3°C and 979.4 hPa.

Based on prediction done using ACD/I-Lab 2.0,the density of chemical 2-Bromoethylamine hydrobromide was estimated to be 1.581 ± 0.06 g/cm3.

As the data from lab has K1 reliability and the test was performed using OECD guidelines which has the value of mean pour density and tapped density as 0.9784 g/cm³ and 1.180 g/cm³at 28.3°C and 979.4 hpa,thus considered as key study for the chemical safety assessment