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Description of key information

Hydrolysis

HYDROWIN v2.00 program of Estimation Programs Interface (EPI Suite, 2017) prediction model was used to predict the hydrolysis half-life of test compound

2-hydroxypropyl octadec-9-enoate (CAS No. 1330 -80 -9). The estimated half-life of 2-hydroxypropyl octadec-9-enoate was estimated to be 7.711 yrs and 281.632 days at pH 7 and 8 (at 25ᵒC) respectively, indicating that it is not rapidly hydrolysable.

Additional information

Hydrolysis

Predicted data for the target chemical 2-hydroxypropyl octadec-9-enoate (CAS No. 1330-80-9) and various studies from authoritative database for its read across substance were reviewed for the hydrolysis end point which are summarized as below:

 

For target chemical 2 -hydroxypropyl octadec-9 -enoate (CAS No. 1330 -80 -9), HYDROWIN v2.00 program of Estimation Programs Interface (EPI Suite, 2017) prediction model was used to predict the hydrolysis half-life of test compound 2 -hydroxypropyl octadec-9-enoate. The estimated half-life of 2-hydroxypropyl octadec-9-enoate was estimated to be 7.711 yrs and 281.632 days at pH 7 and 8 (at 25ᵒC) respectively, indicating that it is not rapidly hydrolysable.

 

In a supporting weight of evidence study from authoritative database (HSDB, 2016), the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the read across chemical methyl dodecanoate (CAS no. 111 -82 -0). The second order hydrolysis rate constant was determined to be 0.030L/mol-sec with a corresponding half-lives of 7.3 yrs and 270 days at pH 7 and 8, respectively.

 

In an another weight of evidence study of read across chemical 6 -O-palmitoylascorbic acid (CAS no. 137 -66 -6) from authoritative database (HSDB, 2016), the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the read across chemical 6 -O-palmitoylascorbic acid. The second order hydrolysis rate constant was determined to be 0.0285L/mol-sec with a corresponding half-lives of 7.7 yrs and 280 days at pH 7 and 8, respectively.

 

On the basis of the above results for target chemical 2-hydroxypropyl octadec-9-enoate(from EPI suite, 2017) and for its read across substance (from authoritative database HSDB, 2016), it can be concluded that the chemical 2 -hydroxypropyl octadec-9 -enoate is not hydrolysable.