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Biodegradation in water

Biodegradability of 2-hydroxypropyl octadec-9-enoate (CAS no. 1330 -80 -9) is predicted using OECD QSAR toolbox version 3.4 with logKow as the primary descriptor. Test substance undergoes 68.16% degradation by BOD in 28 days (2017). Thus, based on percentage degradation, the test chemical 2-hydroxypropyl octadec-9-enoate was estimated to be readily biodegradable in water.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 

2-hydroxypropyl octadec-9-enoate (CAS No. 1330 -80 -9). If released in to the environment, 23.1% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical 2-hydroxypropyl octadec-9-enoate is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical 2-hydroxypropyl octadec-9-enoate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 5% (i.e, reported as 3.29%), indicates that 2-hydroxypropyl octadec-9-enoate is not persistent in sediment.

Biodegradation in soil

The half-life period of 2-hydroxypropyl octadec-9-enoate (CAS No. 1330 -80 -9) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 73.5% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 2-hydroxypropyl octadec-9-enoate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of 2-hydroxypropyl octadec-9-enoate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Additional information

Biodegradation in water

Variouspredicted datafor the target compound 2 -hydroxypropyl octadec-9 -enoate (CAS No. 1330 -80 -9) and various supporting weight of evidence studies for its read across substances were reviewed for the biodegradation end point which are summarized as below:

 

In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.4 with logKow as the primary descriptor, percentage biodegradability of test chemical 2-hydroxypropyl octadec-9-enoate(CAS No. 1330-80-9)was estimated.Test substance undergoes 68.16% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 2-hydroxypropyl octadec-9-enoate was estimated to be readily biodegradable in water.

 

In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound 2-hydroxypropyl octadec-9-enoate(CAS No. 1330-80-9)in the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 2 -hydroxypropyl octadec-9 -enoate is expected to be readily biodegradable.

 

In a supporting weight of evidence study from authoritative database (J-CHECK, 2017) for the read across chemical 2,3 -dihydroxypropyl octadec-9 -enoate (CAS no. 111-03-5), biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test substance 2,3 -dihydroxypropyl octadec-9 -enoate. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance was determined to be 67 and 100% by BOD and HPLC parameter in 28 days. Thus, based on percentage degradation, 2,3 -dihydroxypropyl octadec-9 -enoate is considered to be readily biodegradable in nature.

 

Another weight of evidence of biodegradation studyfor the read across chemical methyl dodecanoate (CAS no. 111 -82 -0) was conducted for 28 days for evaluating the percentage biodegradability of read across substancemethyl dodecanoate (J-CHECK, 2017). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance was determined to be 78 and 100% by BOD and GC parameter in 28 days. The test substance was partially hydrolyzed in water to form dodecanoic acid and methanol. Thus, based on percentage degradation, methyl dodecanoate is considered to be readily biodegradable in nature.

 

On the basis of above results for target chemical 2-hydroxypropyl octadec-9-enoate (from OECD QSAR toolbox version 3.4 and EPI Suite, 2017) and for its read across substance (from authoritative database J-CHECK, 2017), it can be concluded that the test substance 2 -hydroxypropyl octadec-9 -enoate can be expected to be readily biodegradable in nature.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 

2-hydroxypropyl octadec-9-enoate (CAS No. 1330 -80 -9). If released in to the environment, 23.1% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical 2-hydroxypropyl octadec-9-enoate is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical 2-hydroxypropyl octadec-9-enoate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 5% (i.e, reported as 3.29%), indicates that 2-hydroxypropyl octadec-9-enoate is not persistent in sediment.

Biodegradation in soil

The half-life period of 2-hydroxypropyl octadec-9-enoate (CAS No. 1330 -80 -9) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 73.5% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 2-hydroxypropyl octadec-9-enoate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of 2-hydroxypropyl octadec-9-enoate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

On the basis of available information, the test substance 2 -hydroxypropyl octadec-9 -enoate can be considered to be readily biodegradable in nature.