[1aR-(1aα,4aα,7α,8aS*)]-octahydro-4,4,8,8-tetramethyl-4a,7-methano-4aH-naphth[1,8a-b]oxirene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

December, 1969

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study meets the EC Standards (conducted equivalent to OECD 401). Non GLP and only a very short description of method.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1969

Report date:

1969

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

limited study design details in the report, limited details on test material and test animals and no environmental conditions: not expected to affect the outcome of the study

GLP compliance:

no

Remarks:

not present at the time of performance.

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

[1aR-(1aα,4aα,7α,8aS*)]-octahydro-4,4,8,8-tetramethyl-4a,7-methano-4aH-naphth[1,8a-b]oxirene

EC Number:

247-851-6

EC Name:

[1aR-(1aα,4aα,7α,8aS*)]-octahydro-4,4,8,8-tetramethyl-4a,7-methano-4aH-naphth[1,8a-b]oxirene

Cas Number:

26619-69-2

Molecular formula:

C15H24O

IUPAC Name:

[1aR-(1aα,4aα,7α,8aS*)]-octahydro-4,4,8,8-tetramethyl-4a,7-methano-4aH-naphth[1,8a-b]oxirene

impurity 1

Reference substance name:

7,7,8,8-tetramethyloctahydro-2,3b-methanocyclopenta[1,3]cyclopropa[1,2]benzen-4-ol

Cas Number:

29461-20-9

Molecular formula:

C15H24O

IUPAC Name:

7,7,8,8-tetramethyloctahydro-2,3b-methanocyclopenta[1,3]cyclopropa[1,2]benzen-4-ol

Test material form:

liquid

Details on test material:

- Name of test material (as cited in the expert statement): Folenox
- Chemical name: 4,4,8,8-Tetramethyloctahydro-4a,7-methanonaphtho[1,8a-b]oxirene (IUPAC)
- Empirical formula: C15H24O
- Structural formula: See IUCLID section 1

Test animals

Species:

rat

Strain:

not specified

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 148 to 200 g
- Fasting period before study: 12 hours
- Housing: no data

ENVIRONMENTAL CONDITIONS
No data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

No data.

Doses:

100, 316, 1000, 4000 and 6000 mg/kg

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Observations for mortality and signs of effect were made for 7 days and survivors were sacrificed.
- Necropsy of survivors performed: no data

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

> 6 000 mg/kg bw

Based on:

test mat.

Mortality:

No deaths occurred.

Clinical signs:

other: No toxic effects were observed.

Gross pathology:

No data.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

In an acute oral toxicity study with male rats, performed equivalent to OECD 401 guideline, an LD50 >6000 mg/kg bw was determined.

Executive summary:

The test substance GIV 2-3907 - ISOLONGIFOLENE EPOXIDE was tested in an acute oral toxicity study with male rats, performed equivalent to OECD 401 guideline. No deaths occurred and no toxic effects were observed.

Based on the results, an LD50 >6000 mg/kg bodyweight was determined.

Note: Folenox is also named GIV 2 -3907 - Isolongifolene epoxide.