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Administrative data

Description of key information

Acute oral: LD 50 > 5000 mg/kg bw.

No deaths,no signs of systemic toxicity,all animals gained weight during the study.
Acute inhalation:

Waiver is suggested based onthe substancehigh molecular weight size and low water solubility
Acute dermal:

LD50>2000 mg/kg bw, no deaths, no signs of systemic toxicity, all animals gained weight during the study.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw
Quality of whole database:
Key study

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Acute oral: The acute oral median lethal dose (LD50) of the test material, F-3014, in the Sprague-Dawley CD strain rat was found to be greater than 5000 mg.kg bodyweight.

No symbol and risk phrase are required according to the EU labelling regulations

Acute inhalation: waiver is suggested based on its molecular size and low water solubility

Acute dermal:The acute dermal median lethal dose (LD50) of the test material, F-3014, in the Sprague-Dawley CD strain rat was found to be greater than 2000 mg/kg bodyweight.


Justification for selection of acute toxicity – inhalation endpoint
a waiver is suggested: the molecular size of F-3014 is big and water solubility is very low thus the material will not dissolve in the nose and mouth mucus/spit and will not penetrate the cell membrane due to molecular size.

Justification for classification or non-classification

No symbol and risk phrase are required according to EU labelling regulations.

The acute oral median lethal dose (LD50) of the test material, F-3014, in the Sprague-Daweley CD strain rat was found to be greater than 5000 mg.kg bodyweight.

No symbol and risk phrase are required according to the EU labelling regulations

The acute dermal median lethal dose (LD50) of the test material, F-3014 in the Sprague-Dawley CD strain rat was found to be greater than 2000 mg/kg bodyweight.

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