Registration Dossier
Registration Dossier
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EC number: 254-529-9 | CAS number: 39577-43-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Henry F. Smyth Jr., Charles P. Carpenter, Carrol S. Well, Urbano C. Pozzani & Jean A. Striegel
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, 1962, 23:2, 95-107
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Primary dermal irritation study was carried out on rabbits to assess the irritation potential of 2-piperazin-1-ylethanol
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-piperazin-1-ylethanol
- EC Number:
- 203-142-3
- EC Name:
- 2-piperazin-1-ylethanol
- Cas Number:
- 103-76-4
- Molecular formula:
- C6H14N2O
- IUPAC Name:
- 2-piperazin-1-ylethanol
- Test material form:
- solid
- Details on test material:
- InChI: 1S/C6H14N2O/c9-6-5-8-3-1-7-2-4-8/h7,9H,1-6H2
Name of the test chemical: N-(2-Hydroxyethyl)piperazine/
Moolecular formula:C6H14N2O
Molecular weight:130.19 g/mol
Physical State: Solid
Constituent 1
- Specific details on test material used for the study:
- InChI: 1S/C6H14N2O/c9-6-5-8-3-1-7-2-4-8/h7,9H,1-6H2
Name of the test chemical: N-(2-Hydroxyethyl)piperazine/
Molecular formula:C6H14N2O
Molecular weight:130.19 g/mol
Physical State: Solid
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: closely clipped, tact rabbit skij
- Vehicle:
- other: solutions in water, acetone, propylene glycol
- Controls:
- not specified
- Amount / concentration applied:
- 0.01 ml of undiluted sample or of solutions in water, acetone, propylene glycol
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- 5
- Details on study design:
- TEST SITE
Area of exposure: closely clipped, intact abdominal skin
% coverage: No data
Type of wrap if used: no wrap used
REMOVAL OF TEST SUBSTANCE
Washing (if done): no data
Time after start of exposure: no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation was observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- Acute dermal irritation study was carried out to assess the irritation potential of N-(2-Hydroxyethyl)piperazine.
Primary Irritation score after 24 hours for N-(2-Hydroxyethyl)piperazine was Grade 1.
Based on this grade, N-(2-Hydroxyethyl)piperazine can be considered not irritating to rabbit skin. - Executive summary:
Acute dermal irritation study was carried out to assess the irritation potential of N-(2-Hydroxyethyl)piperazine.
Primary skin irritation on rabbits was recorded in a 10-grade ordinal series and was based upon the severest reaction that develops on the clipped abdominal skin of each of five albino rabbits within 24 hours of the uncovered application of 0.01 ml of undiluted sample or of solutions in water, propylene glycol, or acetone.
Grade 1 indicates no irritation and Grade 2 the least visible capillary injection from the undiluted chemical. Grade 6 indicates necrosis when undiluted and Grade 10 indicates necrosis from a 0.01% solution
Primary Irritation score after 24 hours for N-(2-Hydroxyethyl)piperazine was Grade 1.
Based on this grade,N-(2-Hydroxyethyl)piperazine can be considered not irritating to rabbit skin.
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