Reaction products of 7-amino-4-hydroxynaphthalene-2-sulfonic acid reacted with 2-((1,3,5-triazin-2-yl)amino)ethan-1-ol, coupled with diazotised 3-amino-4-hydroxybenzenesulfonic acid, subsequently coupled with diazotised 2-amino-5-methoxybenzenesulfonic acid, chelated with copper, sodium salt

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2015-08-28

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

GLP compliance:

no

Type of method:

flask method

Remarks:

Shake Flask method

Partition coefficient type:

octanol-water

Analytical method:

photometric method

Type:

Pow

Partition coefficient:

ca. 0.007

Temp.:

20 °C

pH:

ca. 9.2

Key result

Type:

log Pow

Partition coefficient:

ca. -2.138

Temp.:

20 °C

pH:

ca. 9.2

Details on results:

The log Kow of the test substance was determined to be -2.1375 (Pow: 0.0074) at 20 °C and pH 9.20.

At 96 hours values reached equilibrium, and so this value was considered for final calculations making duplicate determinations of every ratio o/w. Concentration of mother solution: W 1 = 0.0413 g / 100 mL = 0.4130 g/L

Table 1: Results

Ratio o/w	Water phase	n-octanol phase	Pow	log Pow	Average log Pow
	c (g/l)	c (g/l)
70 / 30	0.4109	0.0037	0.009	-2,046439	-2,1348
70 / 30	0.4119	0.0025	0.006	-2,223088
50 / 50	0.4098	0.0032	0.0077	-2.11171	-2.1117
50 / 50	0.4098	0.0032	0.0077	-2.11171
30 / 70	0.4077	0.0023	0.0056	-2.25559	-2.1661
30 / 70	0.4051	0.0034	0.0084	-2,076681
pH of the test solution:		9.20
Average Pow		0.0074	Average log Pow		-2.1375
Std. dev. Pow		0.0004	Std. dev. log Pow		0.027

Conclusions:

The log Kow of the test substance was determined to be -2.1375 (Pow: 0.0074) at 20 °C and pH 9.20.

Executive summary:

Method

Partition coefficient was determined by means of shake flask method as per recommendations of OECD 107. Partition coefficient (P) is defined as the ratio of the equilibrium concentrations of a dissolved substance in a two-phase system consisting in two largely immiscible solvents.

Result

Study conducted at 20 °C and pH 9.20.

Average Pow = 0.0074 at 20 °C

logPow = -2.1375 at 20 °C

Description of key information

The log Kow of the test substance was determined to be -2.1375 (Pow: 0.0074) at 20 °C and pH 9.20.

Key value for chemical safety assessment

Log Kow (Log Pow):

-2.138

at the temperature of:

20 °C

Additional information

For the determination of the partition coefficient of the test substance a Shake Flask method according to OECD 107 was used. The log Kow of the test substance was determined to be -2.1375 (Pow: 0.0074) at 20 °C and pH 9.20.