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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from safety assessment reports

Data source

Reference
Reference Type:
secondary source
Title:
REPORTS of the Scientific Committee on Cosmetology (seventh series)
Author:
Published by the COMMISSION OF THE EUROPEAN COMMUNITIES; Directorate-General Telecommunications, Information Industries and Innovation
Year:
1988
Bibliographic source:
Scientific Committee on Cosmetology (seventh series), 1988

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To evaluate the dermal irritation potential of the test chemical
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(2-methyl-4-(2-methylphenylazo)phenylazo)-2-naphthol
EC Number:
201-635-8
EC Name:
1-(2-methyl-4-(2-methylphenylazo)phenylazo)-2-naphthol
Cas Number:
85-83-6
Molecular formula:
C24H20N4O
IUPAC Name:
1-(2-methyl-4-(2-methylphenylazo)phenylazo)-2-naphthol
Specific details on test material used for the study:
Name of the test chemical: 1-({2-methyl-4-[(2-methylphenyl)diazenyl]phenyl}diazenyl)-2-naphthol (also known as Solvent Red 24)
Molecular formula: C24H20N40
Molecular weight: 380.48 g/mol
SMILES: Cc1ccccc1N=Nc1ccc(N=Nc2c3ccccc3ccc2O)c(C)c1
Substance Type: Organic
Physical State: Solid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data available

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
other: 0.5 ml 1,2-propanediol
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
not specified
Observation period:
not specified
Number of animals:
not specified
Details on study design:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: not specified
Score:
2.3
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritant / corrosive response data:
Slightly irritating to rabbit skin.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
The irritation index was determined to be 2.3. Based on the scores, the test chemical can be considered as slightly irritating to rabbit skin.
Executive summary:

Skin irritation test was carried out on rabbits with 500 mg of the test chemical in 0.5 ml 1,2-propanediol, and the irritation effects were observed (duration not specified) and scored.

The irritation index was determined to be2.3. Based on the scores, the test chemical can be considered as slightly irritating to rabbit skin.