Registration Dossier
Registration Dossier
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EC number: 257-269-4 | CAS number: 51548-48-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- IUCLID DATASET
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCLID DATASET- EUROPEAN COMMISSION – European Chemicals Bureau, 19–FEB–2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Skin irritation study of 4,4'-Diamino-2,2'-stilbenedisulfonic acid was conducted in rabbits to determine its irritation potential .
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4,4'-Diamino-2,2'-stilbenedisulfonic acid
- IUPAC Name:
- 4,4'-Diamino-2,2'-stilbenedisulfonic acid
- Reference substance name:
- 4,4'-diaminostilbene-2,2'-disulphonic acid
- EC Number:
- 201-325-2
- EC Name:
- 4,4'-diaminostilbene-2,2'-disulphonic acid
- Cas Number:
- 81-11-8
- IUPAC Name:
- 2,2'-ethene-1,2-diylbis(5-aminobenzenesulfonic acid)
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report):4,4'-Diamino-2,2'-stilbenedisulfonic acid
- Molecular formula (if other than submission substance):C14H14N2O6S2
- Molecular weight (if other than submission substance):370.405 g/mol
- Smiles notation (if other than submission substance):S(=O)(=O)(O)c1cc(N)ccc1C=Cc2ccc(N)cc2S(=O)(=O)O
- InChl (if other than submission substance):1S/C14H14N2O6S2/c15-11-5-3-9(13(7-11)23(17,18)19)1-2-10-4-6-12(16)8-14(10)24(20,21)22/h1-8H,15-
16H2,(H,17,18,19)(H,20,21,22)/b2-1+
- Substance type:Organic
- Physical state:solid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No Data Available
- Duration of treatment / exposure:
- No Data Available
- Observation period:
- No Data Available
- Number of animals:
- No Data Available
- Details on study design:
- No Data Available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: No Data Available
- Reversibility:
- no data
- Remarks on result:
- other: non irritant
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material 4,4'-Diamino-2,2'-stilbenedisulfonic acid (CAS No:81-11-8)was found to be non irritant to the rabbits’ skin.
- Executive summary:
The skin irritation study of, 4’-Diamino-2,2'-stilbenedisulfonic acid (CAS No:81-11-8) was performed in rabbits to determine its irritation potential .
Since no irritation was noted the test material 4,4'-Diamino-2,2'-stilbenedisulfonic acid was found to be non irritant on rabbits’ skin.
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