Cyclohexane, oxidized, non-acidic by-products, distn. residues

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Unsuitable test system

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1965

Report date:

1965

Materials and methods

Principles of method if other than guideline:

BASF-Test: The animals were shaved on their ventral side four days before test initiation. Then, the animals were placed for 4 hours in a tub filled with 10-15 g of the undiluted test substance in such a manner that their shaven bellies were exposed to the test compound. At the end of the exposure period, the animals were washed with concentrated lutrol and dried by means of tissue paper. The test animals were observed for clinical signs and lethality several times during the exposure period and then daily during the 6-11 days observation period. Animals that died during the course of the study were submitted to necropsy.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Cyclohexane, oxidized, non-acidic by-products, distn. residues

EC Number:

271-816-4

EC Name:

Cyclohexane, oxidized, non-acidic by-products, distn. residues

Cas Number:

68609-04-1

IUPAC Name:

(1s,4s)-cyclohexane-1,4-diol (cyclohexyloxy)cyclohexane 2-butylcyclohexan-1-one 8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7)-diene cyclohexane cyclohexane-1,3-diol cyclohexanol phenol hydrate

Details on test material:

- Name of test material (as cited in study report): Anone destillation residue

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Mean weight at study initiation: 110 g

Administration / exposure

Type of coverage:

other: exposed skin was submerged in test substance

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

10 white rabbits were fixed with their stomach onto a special bowl containing 10-15g of the test solution. By doing so a 25-65 cm2 area of the shaved skin were exposed for 4h. The post-exposure observation period was 6-11 days.

Duration of exposure:

4 h

Doses:

10-15 g

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 8-11 days
- Frequency of observations: The test animals were observed for clinical signs and lethality several times during the exposure period and then daily during the 8-11 days of observation period.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Mortality:

no mortalities were observed

Clinical signs:

Apathy was observed on the day of treatment. No symptoms were observed one day after exposure.

Gross pathology:

no abnormalities were detected