Registration Dossier
Registration Dossier
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EC number: 212-889-4 | CAS number: 877-24-7
Endpoint summary
Administrative data
Description of key information
Based on the predicted data by BCFBAF Program (v3.01) model of EPI suite the Bioaccumulation factor (BCF) was predicted to be 3.162 L/kg wet-wt at 25 deg.C.Based on the BCF concentration it is concluded that the test chemical hydrogen potassium phthalate in non bioaccumulative in nature as it dose not exceed the BCF criteria of 2000.
Additional information
Experimental and Predicted data of Bioaccumulation endpoint for the target chemical hydrogen potassium phthalate (Cas no. 877-24-7) and its read across chemical were reviewed to summarize as follows:
From predicted model EPI suite 2017 using BCFBAF Program (v3.01) indicate that Bioaccumulation factor (BCF) was predicted to be 3.162 L/kg wet-wt at 25 deg.C. Based on the BCF concentration it is concluded that the test chemical hydrogen potassium phthalate in non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
Whereas from PBT profiler computational model the Bio concentration factor (BCF) was estimated to be 3.2 for test substance hydrogen potassium phthalate.
From HSDB database (2017); for the read across chemical Phthalic acid (Cas no. 88-99-3) an estimated BCF of 3 was calculated, using a log Kow of 0.73 and a regression-derived equation ,this BCF suggests the potential for bioconcentration in aquatic organisms is negligible.
And information from an authorative database ECOTOX (2017) for read across Benzoic Acid (Cas no. 65-85-0) indicates, on the basis of accumulation effect, the Bioconcentration factor (BCF) for test substance Benzoic acid was observed to be 21 for dose concentration 1.78 ug/L in fish Gambusia affinis (Western Mosquitofish) for exposure period of 24 hrs. Based on the result it is concluded that the test substance is non bioaccumulative in nature.
Thus based on the above all studies it is concluded that the test substance hydrogen potassium phthalate (Cas no. 877-24-7) is non Bioaccumulative in aquatic environment.
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