Potassium hydrogen phthalate

Density

Link to relevant study record(s)

Reference

Endpoint:

density, other

Remarks:

mean pour density and tapped density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-01-07 – 2017-01-07

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental result using standard methods analysis

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Principles of method if other than guideline:

The density of Test item Potassium hydrogen phthalate (CAS No. 877-24-7 ) was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.

GLP compliance:

not specified

Type of method:

other: mean pour density and tapped density

Specific details on test material used for the study:

- Name of test material (as cited in study report): Hydrogen potassium phthalate
- Molecular formula : C8H5O4K
- Molecular weight : 204.221 g/mol
- Smiles notation : c1(c(cccc1)C(=O)[O-])C(O)=O.[K+]
- InChl : 1S/C8H6O4.K/c9-7(10)5-3-1-2-4-6(5)8(11)12;/h1-4H,(H,9,10)(H,11,12);/q;+1/p-1
- Substance type:Organic
- Physical state:Solid

Key result

Type:

pour density

Density:

0.909 g/cm³

Temp.:

25.9 °C

Key result

Type:

tap density

Density:

1 g/cm³

Temp.:

25.9 °C

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Method Details		Observations
Guideline	OECD 109	1^stReading	2^ndReading
Method	Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014
Principle of method	Pour Density:It is the ratio of known weight of test item and its volume in graduated glass cylinder. Tap Density: It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.
Test temperature (°C)		25.9°C	25.9°C
Atmospheric pressure (in hPa)		976.4	977.1
Weight of test item(m)		20.005	20.002
Volume of measuring cylinder; readability in g		250ml ; 2 ml	250 ml; 2ml
Volume of test item without tapping (V)		22	22
Volume of test item after tapping ( V1)	After 10 tapping	20	20
	After 50 tapping	20	20
	After 100 tapping	20	20
	After 250 tapping	-	-
	After 500 tapping	-	-
	After 750 tapping	-	-

 

CALCULATIONS:

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Parameters	Details	Calculated values		Average Density
		1st Calculation	2nd Calculation
Pour Density of test Item (g/cm³)	m/v	20.005/22 =0.9093	20.002/22 =0.9091	0.9092
Tap density of test Item (g/cm³)	m/v	20.005/20 =1.000	20.002/20 =1.000	1.000

 

Conclusions:

The density of Potassium hydrogen phthalate (CAS No. 877-24-7)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus.The mean pour density and tapped density of chemical Potassium hydrogen phthalatwas determined to be 0.9092 g/cm³ and 1.000 g/cm³at 25.9°C and 976.7 hPa.

Executive summary:

The density of Potassium hydrogen phthalate (CAS No. 877-24-7)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus.The mean pour density and tapped density of chemical Potassium hydrogen phthalat was determined to be 0.9092 g/cm³ and 1.000 g/cm³at 25.9°C and 976.7 hPa.

Description of key information

The density of Potassium hydrogen phthalate (CAS No. 877-24-7)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus.The mean pour density and tapped density of chemical Potassium hydrogen phthalatwas determined to be 0.9092 g/cm³ and 1.000 g/cm³at 25.9°C and 976.7 hPa.

Key value for chemical safety assessment

Relative density at 20C:

0.909

Additional information

The density of Potassium hydrogen phthalate (CAS No. 877-24-7)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus.The mean pour density and tapped density of chemical Potassium hydrogen phthalatwas determined to be 0.9092 g/cm³ and 1.000 g/cm³at 25.9°C and 976.7 hPa.

Other supporting study from various reliable handbooks suggests that the density of chemical Hydrogen potassium phthalate was reported to be 1.636 g/cm3 at 25 degree C.

As the data from lab has K1 reliability and the test was performed using OECD guidelines which has the value of mean pour density and tapped density as 0.9092 g/cm³ and 1.000 g/cm³ respectively,thus considered as key study for the chemical safety assessment.