Registration Dossier
Registration Dossier
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EC number: 201-166-9 | CAS number: 79-00-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1976
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Test conditions, design and results not sufficiently described.
Data source
Reference
- Reference Type:
- publication
- Title:
- Irritating power of the principal aliphatic chloride solvents on the skin and ocular mucosa of the rabbit
- Author:
- Duprat, P., Delsaut, L., Gradiski, D.
- Year:
- 1 976
- Bibliographic source:
- Eur. J. Toxicol. Environ., 9, 171-177
Materials and methods
- Principles of method if other than guideline:
- Draize method
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,1,2-trichloroethane
- EC Number:
- 201-166-9
- EC Name:
- 1,1,2-trichloroethane
- Cas Number:
- 79-00-5
- Molecular formula:
- C2H3Cl3
- IUPAC Name:
- 1,1,2-trichloroethane
- Details on test material:
- Name of the test substance (as cited in the test report) : 1,1,2-trichloroethane.
- Analytical purity: > 98%
- Density: 1.443
- Origin: FLUCKA
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- application of 1,1,2-trichloroethane at 162 mg (0.1 ml) into the conjunctival sac of the rabbit eye
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 162 mg (0.1 ml)
- Observation period (in vivo):
- 24h, 7 and 14 days
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- animal #6
- Time point:
- other: 2 weeks
- Score:
- 8
- Max. score:
- 110
- Reversibility:
- fully reversible within: after 2 weeks
- Other effects:
- After application of 1,1,2-trichloroethane at 162 mg (0.1 ml) into the conjunctival sac of the rabbit eye, a weak catarrhalic conjunctivitis as well as epithelial abrasion were observed. In addition, a healing keratitis was observed after 7 days. These symptoms completely disappeared within 2 weeks.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Kay and Calandra (1962)
- Conclusions:
- Under test conditions, 1,1,2-trichloroethane is considered to be slightly irritating to eyes.
- Executive summary:
After application of 1,1,2-trichloroethane at 162 mg (0.1 ml) into the conjunctival sac of the rabbit eye, a weak catarrhalic conjunctivitis as well as epithelial abrasion were observed. In addition, a healing keratitis was observed after 7 days. These symptoms completely disappeared within 2 weeks.
Under test conditions, 1,1,2-trichloroethane is considered to be slightly irritating to eyes.
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