Registration Dossier
Registration Dossier
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EC number: 232-260-8 | CAS number: 7803-51-2
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Value:
- 0.14
Acute/short term exposure
- Value:
- 0.28 mg/m³
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
In 1998, the SCOEL considered the several repeated inhalation exposure studies in animals to form the best basis for deriving suitable occupational exposure limits. On the basis of NOAEL ranging between 0.3 to 1.0 ppm, the SCOEL recommended an 8 hours TWA of 0.1 ppm (0.14 mg/m3) and a STEL (15 mn) of 0.2 ppm (0.28 mg/m3) limit peaks in exposure which could result in irritation. The SCOEL considered a skin notation is not necessary.
A new study was available in 1999 (Newton et al.). According to ECHA guidance document R.8 (Appendix R8.-13, May 2008) a DNEL was established on the basis of this study and the value indicates that the IOEL provides the appropriate level of protection required by REACH.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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