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EC number: 229-186-3 | CAS number: 6424-76-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The LD50 (oral) was determined for male/female rats. No effects were observed up to a concentration of 5000 mg/kg bw, during a period of 14 d after application (gavage). Therefore, the LD50 is considered to be >5000 mg/kg bw. The classification criteria for CLP are not met.
The LC50 (inhalation) could not be determined for male/female rats. No effects were observed during a period of 14 d after an 8 h exposure (dust). Therefore, the classification criteria for CLP are not met.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Herilan MRH-Haltung, Eggersmann KG, Germany
- Females (if applicable) nulliparous and non-pregnant: yes
- Weight at study initiation: male (mean): 180 g, female (mean): 160 g
- Fasting period before study: 15 - 20 h prior to application - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50%
- Amount of vehicle (if gavage): 10 mL/kg
- Justification for choice of vehicle: dispersion used for application
MAXIMUM DOSE VOLUME APPLIED: 5000 mg/kg - Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of observations and weighing: 2-4 d, 7 d, 13 d after application
- Necropsy of survivors performed: yes - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed
- Body weight:
- Male (mean): 266 g (+ 86 g gain)
Female (mean): 196 g (+ 36 g gain) - Gross pathology:
- Faeces stained blue.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on an oral limit test with 5000 mg/kg bw where no mortality or any other toxicological symptoms occured within 14 d after application (gavage) in male and female rats, the test item is not classifiable according to CLP criteria.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Inhalation risk test according to H F Smyth et al. (1962).
- GLP compliance:
- no
- Test type:
- concentration x time method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Firma Wiga, Sulzfeld, Germany
- Weight at study initiation: mean: 215 g
- Housing:
- Diet (e.g. ad libitum): ad lib.
- Water (e.g. ad libitum): ad lib.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C
- Air changes (per hr): 200 L/h - Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- - Temperature: 20°C
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Remarks on duration:
- also determined: 3, 10, 30 min and 1, 3 h
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Exp. duration:
- 8 h
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No mortality observed.
- Clinical signs:
- other: No signs of toxic effect observed.
- Gross pathology:
- Organs without any findings.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an inhalation risk test performed with 6 female and 6 male rats, no mortality or other toxic effects occured after 8 h exposure (dust) and during the post exposure period of 14 d.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Justification for classification or non-classification
No adverse were observed for oral exposure and via inhalation.
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