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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Not specified
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted to GLP (taken from SNIF file). Registrant referring to studies >12 years old at the permission of ECHA.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method C.2 (Acute Toxicity for Daphnia)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
4,6-bis(octylthiomethyl)-o-cresol
EC Number:
402-860-6
EC Name:
4,6-bis(octylthiomethyl)-o-cresol
Cas Number:
110553-27-0
Molecular formula:
C25H44OS2
IUPAC Name:
4,6-bis(octylthiomethyl)-o-cresol

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
yes
Details on test solutions:
Identity and concentration of auxiliary solvent for dispersal: 1 g of the substance was dissolved in and made up to 10 ml with DMF. This solution was diluited to a concentration of 100 mg/l with water containing 2.3 mg/l Alkylphenol-polyglycolether.

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
48 h

Test conditions

Hardness:
240 mg CaCO3/l
Test temperature:
Not specified
pH:
Not specified
Dissolved oxygen:
Not specified
Salinity:
Not applicable.
Nominal and measured concentrations:
Not specified
Details on test conditions:
Not specified
Reference substance (positive control):
not specified

Results and discussion

Effect concentrationsopen allclose all
Duration:
24 h
Dose descriptor:
LC0
Effect conc.:
< 0.5 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: The immobility of most daphnias was affected by deposits of the test substance on their body. Therefore EC50 could not be determined.
Duration:
24 h
Dose descriptor:
LC100
Effect conc.:
> 5.5 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: The immobility of most daphnias was affected by deposits of the test substance on their body. Therefore EC50 could not be determined
Details on results:
The immobility of most daphnias was affected by deposits of the test substance on their body. Therefore EC50 could not be determined
Results with reference substance (positive control):
Not specified
Reported statistics and error estimates:
Not specified

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The immobility of most daphnias was affected by deposits of the test substance on their body. Therefore EC50 could not be determined. These effects are considered to be physical, and not attributable to toxicity.
Executive summary:

The immobility of most daphnias was affected by deposits of the test substance on their body. Therefore EC50 could not be determined. These effects are considered to be physical, and not attributable to toxicity. No classification is applicable.