Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27 Janaury 2011 to 11 February 2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted to OECD test guidance in compliance with GLP and reoprted with a valid GLP certificate

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2011
Report date:
2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
4,6-bis(octylthiomethyl)-o-cresol
EC Number:
402-860-6
EC Name:
4,6-bis(octylthiomethyl)-o-cresol
Cas Number:
110553-27-0
Molecular formula:
C25H44OS2
IUPAC Name:
4,6-bis(octylthiomethyl)-o-cresol
Details on test material:
Name: THANOX 1520
Batch No.: 031006013
Purity: 99.7 %
Description: pale yellow to colourless liquid
Manufacture date: 25 June 2010
Expiry date: 25 June 2011
Manufacturer: Rianlon Chemical Co. Ltd.
Storage: room temperature, protect from light and humidity, under N2

The test item of a suitable chemical purity was supplied by the Sponsor. All safety instructions required in the handling and disposal of the test item were supplied by the Sponsor as well.
The identification of test item was made by its appearance and colour by Central Dispensary Unit of LAB Research Ltd.

Results and discussion

Dissociating properties:
no

Any other information on results incl. tables

Table 1. Results of titration with standard base solution

Water

Water + acetone

Measurement 1

Measurement 2

Measurement 3

Volume

(ml)

pH

Volume

(ml)

pH

Volume

(ml)

pH

Volume

(ml)

pH

Volume

(ml)

pH

0.004

5.848

0.004

6.001

0.004

5.907

0.004

5.812

0.004

5.854

0.176

5.946

0.208

6.078

0.144

5.955

0.176

5.912

0.224

5.953

0.316

6.042

0.300

6.117

0.284

6.068

0.316

6.005

0.300

6.003

0.488

6.199

0.472

6.247

0.488

6.252

0.718

6.470

0.500

6.156

0.758

6.569

0.808

6.834

0.758

6.571

0.938

6.756

0.704

6.338

0.930

6.837

1.276

7.875

1.028

7.098

1.274

7.666

1.056

6.871

1.412

8.252

1.612

8.352

1.200

7.554

1.544

8.209

1.618

8.131

1.814

8.643

2.094

8.666

1.536

8.117

2.106

8.648

2.100

8.573

2.216

8.808

2.576

8.901

2.114

8.643

2.508

8.816

2.582

8.812

2.778

8.994

3.154

9.039

2.596

8.876

3.070

8.973

3.064

8.940

 

Table 2. Results of titration with standard acid solution

Water

Water + acetone

Measurement 1

Measurement 2

Measurement 3

Volume

(ml)

pH

Volume

(ml)

pH

Volume

(ml)

pH

Volume

(ml)

pH

Volume

(ml)

pH

0.004

5.562

0.004

5.711

0.004

5.941

0.004

5.987

0.004

5.855

0.224

5.278

0.274

5.335

0.208

5.463

0.224

5.693

0.224

5.602

0.364

5.045

0.414

5.167

0.494

5.071

0.428

5.366

0.494

5.244

0.536

4.806

0.766

4.832

0.666

4.919

0.600

5.153

0.666

5.033

0.806

4.568

1.036

4.701

0.870

4.770

0.936

4.912

0.870

4.881

1.208

4.396

1.678

4.481

1.074

4.688

1.418

4.680

1.140

4.734

1.610

4.342

2.080

4.401

1.476

4.545

1.770

4.600

1.476

4.629

2.092

4.263

2.562

4.319

2.198

4.383

2.172

4.517

2.134

4.471

2.670

4.193

3.204

4.248

3.000

4.274

2.734

4.401

2.536

4.394

3.312

4.136

4.006

4.173

3.962

4.173

3.216

4.353

3.018

4.336

 

Applicant's summary and conclusion

Conclusions:
Considering that there was no difference between the titration curve of sample and the control samples; it is concluded that the test item THANOX 1520 has no dissociable group; therefore the dissociation constant is not applicable for this test substance.
Executive summary:

This study has been performed in accordance with the study plan, OECD Guideline for Testing of Chemicals, OECD 112, “Dissociation Constants in Water”, Adopted: 12 May 1981and the Principles of Good Laboratory Practice (GLP) and reported with a valid GLP certificate.

 

Summary of the results:

Considering that there was no difference between the titration curve of sample and the control samples; it is concluded that the test item THANOX 1520 has no dissociable group; therefore the dissociation constant is not applicable for this test substance.