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EC number: 402-860-6 | CAS number: 110553-27-0 CG 25-1320; IRGANOX 1520; TK 12229/1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 Janaury 2011 to 11 February 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to OECD test guidance in compliance with GLP and reoprted with a valid GLP certificate
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4,6-bis(octylthiomethyl)-o-cresol
- EC Number:
- 402-860-6
- EC Name:
- 4,6-bis(octylthiomethyl)-o-cresol
- Cas Number:
- 110553-27-0
- Molecular formula:
- C25H44OS2
- IUPAC Name:
- 4,6-bis(octylthiomethyl)-o-cresol
- Details on test material:
- Name: THANOX 1520
Batch No.: 031006013
Purity: 99.7 %
Description: pale yellow to colourless liquid
Manufacture date: 25 June 2010
Expiry date: 25 June 2011
Manufacturer: Rianlon Chemical Co. Ltd.
Storage: room temperature, protect from light and humidity, under N2
The test item of a suitable chemical purity was supplied by the Sponsor. All safety instructions required in the handling and disposal of the test item were supplied by the Sponsor as well.
The identification of test item was made by its appearance and colour by Central Dispensary Unit of LAB Research Ltd.
Constituent 1
Results and discussion
- Dissociating properties:
- no
Any other information on results incl. tables
Table 1. Results of titration with standard base solution
Water |
Water + acetone |
Measurement 1 |
Measurement 2 |
Measurement 3 |
|||||
Volume (ml) |
pH |
Volume (ml) |
pH |
Volume (ml) |
pH |
Volume (ml) |
pH |
Volume (ml) |
pH |
0.004 |
5.848 |
0.004 |
6.001 |
0.004 |
5.907 |
0.004 |
5.812 |
0.004 |
5.854 |
0.176 |
5.946 |
0.208 |
6.078 |
0.144 |
5.955 |
0.176 |
5.912 |
0.224 |
5.953 |
0.316 |
6.042 |
0.300 |
6.117 |
0.284 |
6.068 |
0.316 |
6.005 |
0.300 |
6.003 |
0.488 |
6.199 |
0.472 |
6.247 |
0.488 |
6.252 |
0.718 |
6.470 |
0.500 |
6.156 |
0.758 |
6.569 |
0.808 |
6.834 |
0.758 |
6.571 |
0.938 |
6.756 |
0.704 |
6.338 |
0.930 |
6.837 |
1.276 |
7.875 |
1.028 |
7.098 |
1.274 |
7.666 |
1.056 |
6.871 |
1.412 |
8.252 |
1.612 |
8.352 |
1.200 |
7.554 |
1.544 |
8.209 |
1.618 |
8.131 |
1.814 |
8.643 |
2.094 |
8.666 |
1.536 |
8.117 |
2.106 |
8.648 |
2.100 |
8.573 |
2.216 |
8.808 |
2.576 |
8.901 |
2.114 |
8.643 |
2.508 |
8.816 |
2.582 |
8.812 |
2.778 |
8.994 |
3.154 |
9.039 |
2.596 |
8.876 |
3.070 |
8.973 |
3.064 |
8.940 |
Table 2. Results of titration with standard acid solution
Water |
Water + acetone |
Measurement 1 |
Measurement 2 |
Measurement 3 |
|||||
Volume (ml) |
pH |
Volume (ml) |
pH |
Volume (ml) |
pH |
Volume (ml) |
pH |
Volume (ml) |
pH |
0.004 |
5.562 |
0.004 |
5.711 |
0.004 |
5.941 |
0.004 |
5.987 |
0.004 |
5.855 |
0.224 |
5.278 |
0.274 |
5.335 |
0.208 |
5.463 |
0.224 |
5.693 |
0.224 |
5.602 |
0.364 |
5.045 |
0.414 |
5.167 |
0.494 |
5.071 |
0.428 |
5.366 |
0.494 |
5.244 |
0.536 |
4.806 |
0.766 |
4.832 |
0.666 |
4.919 |
0.600 |
5.153 |
0.666 |
5.033 |
0.806 |
4.568 |
1.036 |
4.701 |
0.870 |
4.770 |
0.936 |
4.912 |
0.870 |
4.881 |
1.208 |
4.396 |
1.678 |
4.481 |
1.074 |
4.688 |
1.418 |
4.680 |
1.140 |
4.734 |
1.610 |
4.342 |
2.080 |
4.401 |
1.476 |
4.545 |
1.770 |
4.600 |
1.476 |
4.629 |
2.092 |
4.263 |
2.562 |
4.319 |
2.198 |
4.383 |
2.172 |
4.517 |
2.134 |
4.471 |
2.670 |
4.193 |
3.204 |
4.248 |
3.000 |
4.274 |
2.734 |
4.401 |
2.536 |
4.394 |
3.312 |
4.136 |
4.006 |
4.173 |
3.962 |
4.173 |
3.216 |
4.353 |
3.018 |
4.336 |
Applicant's summary and conclusion
- Conclusions:
- Considering that there was no difference between the titration curve of sample and the control samples; it is concluded that the test item THANOX 1520 has no dissociable group; therefore the dissociation constant is not applicable for this test substance.
- Executive summary:
This study has been performed in accordance with the study plan, OECD Guideline for Testing of Chemicals, OECD 112, “Dissociation Constants in Water”, Adopted: 12 May 1981and the Principles of Good Laboratory Practice (GLP) and reported with a valid GLP certificate.
Summary of the results:
Considering that there was no difference between the titration curve of sample and the control samples; it is concluded that the test item THANOX 1520 has no dissociable group; therefore the dissociation constant is not applicable for this test substance.
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