Registration Dossier
Registration Dossier
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EC number: 700-585-9 | CAS number: 35786-94-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP-Study, but well documented.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- not specified
Results and discussion
Any other information on results incl. tables
RESULTS AND DISCUSSION
The rabbit with unwashed eyes pawed the treated eye after instillation of the test substance. The
test substance produced moderate conjunctival redness and minimal discharge in the treated
unwashed rabbit eye. Minimal discharge was observed in the eye washed after treatment.
Fluorescein stain examinations were negative for corneal injury in the treated eyes of both
rabbits. The treated washed eye was normal by 1 day, and the treated unwashed eye was normal
by 2 days after instillation. No clinical signs were observed, and no body weight loss occurred
during the study.
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, the test substance was a moderate eye irritant. If these test scores are to be used for EEC/OECD classification, according to the guide to the labeling of dangerous substances published in the Official Journal of European Communities
(67/548/EEC), the test substance probably should not be classified as irritant unless additional testing
proves otherwise.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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