1-(2-aminoethyl)imidazolidin-2-one

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2015-11-02 until 2015-11-24

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

OECD Guidelines for the Testing of Chemicals No. 104: "Vapour Pressure", March 23, 2006

Deviations:

yes

Remarks:

Program error in the measurement method. The measurement was performed with a ramp 10 °C/min instead of 20°C/min. This change has no impact on the result.

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

Guideline A.4: “Vapour Pressure", Official Journal of the European Union No. L220, August 24, 2009

Deviations:

yes

Remarks:

Program error in the measurement method. The measurement was performed with a ramp 10 °C/min instead of 20°C/min. This change has no impact on the result.

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: isothermal thermogravimetry

Key result

Temp.:

20 °C

Vapour pressure:

0.129 Pa

Temp.:

60 °C

Vapour pressure:

3.64 Pa

Transition / decomposition:

no

Results and Discussion

Results: According to Sponsor Information (Safety Data Sheet) the melting point of the test item is approximately 55 °C. The measurements were done applying temperatures between 140 °C and 200 °C (above the melting point).

 

The detailed results are shown in the following table:

Weight loss of the test item in the temperature range of 160°C to 190 °C

 

Temperature (°C)		Weight loss (µg/min)	vT (g/cm²h)	Log vT
160		219.5	0.026340	-1.579384
160		243.7	0.029244	- 1.533963
160		250.5	0.030060	-1.522011
170	343.3		0.041196	-1.385145
170	369.7		0.044364	-1.352969
170	372.4		0.044688	-1.349809
180	503.9		0.060468	-1.218474
180	533.7		0.064044	-1.193522
180	519.8		0.062376	-1.204982
190	666.4		0.079968	-1.097084
190	758.7		0.091044	-1.040749
190	676.2		0.081144	-1.090744

 

Estimation of log vT at 20°C= -4.9993280

Estimation of log pT at 20°C= -0.8897350

Estimation of pT at 20°C= 0.12890360 = 1.29E-01 Pa

 

Estimation of log vT at 60°C= -3.7125258

Estimation of log pT at 60°C= 0.5614911

Estimation of pT at 60°C= 3.64326799 = 3.64E+00 Pa

 

Extrapolation of the curve to 20 °C and to 60 °C and fitting this value in the regression curve, a vapour pressure of:

at 20 °C: 1.29 x 10-1 Pa

at 60 °C: 3.64 Pa

were obtained (temperature program 140 °C to 200 °C, evaluation at 160 °C to 190 °C).

The determination was performed above the melting point of the test item; these values however are expected to be overestimated, because it was determined from the molten material.

 

Conclusion:The isothermal thermogravimetric effusion method was chosen for the determination of the vapour pressure of AEEU. The vapour pressure of the test item was determined above the melting point and was:at 20 °C: 1.29 × 10-1 Pa (mean of three determinations); at 60 °C: 3.64 Pa (mean of three determinations).

 

Conclusions:

The vapour pressure of the test item was 1.29 × 10-1 Pa at 20 °C and 3.64 Pa at 60 °C.

Executive summary:

The vapour pressure of the test item was measured with the Isothermal Thermogravimetry method according to OECD 104, EU A.4 and GLP. The vapour pressure of the test item was determined above the melting point and was 1.29 × 10-1 Pa at 20°C and 3.64 Pa at 60°C.

Description of key information

The vapour pressure of the test item was measured with the Isothermal Thermogravimetry method according to OECD 104, EU A.4 and GLP. The vapour pressure of the test item was determined above the melting point and was 1.29 × 10-1 Pa at 20°C and 3.64 Pa at 60°C.