Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-983-0 | CAS number: 90-30-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The PBT Assessment for N-1-naphthylaniline (CAS 90-30-2) is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2012).
Persistence
In two screening tests on ready biodegradability (OECD 301C), N-phenyl-1-naphtylamine was shown to be not biodegradable by activated sludge (0% degradation in 14 and 28 days, respectively; Bayer 1990, MITI 1992). Results from these studies can be interpreted as screening criteria towards persistency. However, due to the fact that the test methodology for the screening tests on ready biodegradability is stringent, a negative result does not necessarily mean that the chemical will not be degraded under environmental conditions.
On the other hand, other available biodegradation studies (Sikka et al. 1981, Rosenberg 1983) report 50% degradation within 5 days and 97% degradation within 18 d (supplemented sewage, half-life 4.2 d). In supplemented sewage, more than 75% degradation was observed after 2 d. No test substance could be detected after 18 d (half-life 1.2 d). In lake water, 50% degradation within 10 d was observed, further nutrient supplementation resulted in continued degradation (90% after 18 d, half-life 7.2 d). Transient degradation products were identified as the dihydroxy derivate of N-phenyl-1-naphtylamine and N-acetyl N-phenyl-1-naphtylamine. The substance showed also to be degraded and mineralized in the terrestrial environment. From carbon-supplemented soil 12.5% of the initial radioactivity were evolved as 14CO2 after 11 days. Similar results were obtained with supplemented soil suspensions. After 11 days 22% of radioactivity was recovered as 14CO2. The reported half-life value is below the persistence criteria of 40 d (water) set in Annex XIII to REACH Regulation (EC) No 1907/2006. Thus, the substance is not considered to be P or vP.
Bioaccumulation
Several studies on the bioaccumulation of N-phenyl-1-naphtylamine in fish and daphnids indicated a moderate bioaccumulation potential of the substance. It was shown that the substance accumulates in carp with BCF values ranging from 427 to 2490. Radiolabelled N-phenyl-1-naphtylamine was readily taken up in bluegill sunfish with bioconcentration factors of 600 for whole fish, 339 for edible flesh and 2063 for viscera. Half of the 14C-N-phenyl-1-naphtylamine-derived radioactivity in the fish was eliminated in about 2 days after transfer to clean flowing water, with about 50% of the radioactivity present as N-phenyl-1-naphtylamine metabolite(s). A major metabolite in the fish extract was identified as a dihydroxy derivative of PNA. For Daphnia magna, a BCF of 637 was measured, with an elimination of half of the 14C-N-phenyl-1-naphtylamine derived radioactivity within about 2 days after transfer to clean water. QSAR calculations using the Arnot-Gobas method (including biotransformation) of BCFBAF v3.01 resulted in BCF value of 592.5 and a BAF value of 594.9 L/kg ww. Based on these data evaluated in a weight-of evidence approach, the BCF value for whole organisms is below the bioascumualtion criterion of 2000 set in Annex XIII to REACH regulation (EC) No 1907/2006. Thus the substance is not considered to be B or vB.
Toxicity
N-1-naphthylaniline (CAS 90-30-2) is considered to be toxic. The long-term toxicity of the substance is > 0.01 mg/L. The substance is not classified for carcinogenicity, mutagenicity or reproductive and developmental toxicity in mammals (see section 5.9). However, the substance is classified for chronic toxicity as for specific target organ toxicity after repeated exposure (STOT RE Cat. 2). The criteria for “T” based on mammalian effects are met and thus, the criteria set out in Annex XIII of Regulation (EC) No. 1907/2006 are met and the substance is considered to be T.
Conclusion
The data show that whilst the properties of the substance meet the criteria for toxic, T, they do not meet the specific criteria detailed in Annex XIII of Regulation (EC) No. 1907/2006 for persistence and bioaccumulation and therefore N-1-naphthylaniline (CAS 90-30-2) is not classified as PBT and vPvB.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.