Registration Dossier
Registration Dossier
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EC number: 444-140-4 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 444-140-4
- EC Name:
- -
- Cas Number:
- 18934-00-4
- Molecular formula:
- C12H22O3
- IUPAC Name:
- 3-ethyl-3-{[(3-ethyloxetan-3-yl)methoxy]methyl}oxetane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Physical form of substance: L
Mass median aerodynamic diameter (for liq.+solid aerosol):
3.21 μm
Test animals
- Species:
- other: Sprague-Dawley CD
Administration / exposure
- Vehicle:
- other: none
- Details on inhalation exposure:
- Aerosol atmosphere
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 4.78 mg/L air
- Mortality:
- Male: 4.78 mg/L; Number of animals: 5; Number of deaths: 0
Female: 4.78 mg/L; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: There were no deaths during the study. Common abnormalities noted during the study included increased respiratory rate, haunched posture, pilo-erection and wet fur. All animals recovered quickly to appear normal f
- Gross pathology:
- Effects on organs:
No macroscopic abnormalities were detected at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
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