3,3'-dimethyleneoxybis(3-ethyloxetane)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Year:

2003

Report date:

2003

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Annex V (Acute Toxic Class Method).

GLP compliance:

yes

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

444-140-4

EC Name:

-

Cas Number:

18934-00-4

Molecular formula:

C12H22O3

IUPAC Name:

3-ethyl-3-{[(3-ethyloxetan-3-yl)methoxy]methyl}oxetane

Test material form:

liquid

Test animals

Species:

other: Rat (Sprague-Dawley)

Administration / exposure

Vehicle:

arachis oil

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

< 2 000 mg/kg bw

Mortality:

Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 1
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 3
Female: 300 mg/kg bw; Number of animals: 3; Number of deaths: 0

Clinical signs:

other: Signs of toxicity related to dose levels: Signs of systemic toxicity noted in animals treated at a dose level of 2000 mg/kg were hunched posture, decreased respiratory rate, laboured and/or noisy respiration, occasional body tremors and coma. Four animals

Gross pathology:

Effects on organs:
Abnormalities noted at necropsy of animals that died during
the study were dark liver, pale liquid present in the
stomach and sloughing of the non-glandular region of the
stomach.
No abnormalities were noted at necropsy of animals killed at
the end of the study period.

Applicant's summary and conclusion

Interpretation of results:

other: harmful