Registration Dossier
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EC number: 918-906-8 | CAS number: 65684-27-7
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 82.6% in 28 days (OECD 301B); read across
Key value for chemical safety assessment
Additional information
Experimental data investigating the biodegradability of Glyceryl
undecylenate (CAS 123759-97-7) are not available. The assessment was
therefore based on a weight of evidence approach. The WoE comprises a
study conducted with the structural analogue substance Glycerides,
C8-10, mono- and di- (CAS 85536-07-8; in accordance to Regulation (EC)
No. 1907/2006 Annex XI, 1.5) and QSAR calculations for the main
substance components. The target and the source substances are esters of
a tri-functional alcohol (glycerol) with one or more carboxylic (fatty)
acid(s) chain(s). The alcohol moiety (glycerol) is common to the
analogue substances. The fatty acid moiety comprises carbon chain
lengths from C8-C11 and includes mainly linear saturated alkyl chains,
but also unsaturated chains bound to the alcohol, resulting in mono-,
di-, and tri-esters. The read-across study was conducted according to
OECD Guideline 301B, under GLP conditions (Flach, 2012). Activated
sludge microorganisms were exposed to the test substance for a period of
28 days, and biodegradation followed by measuring the CO2 production in
the test vessels. After 28 days, the test substance reached 82.6%
biodegradation, and therefore, it can be considered as readily
biodegradable. The results obtained in the toxicity control (81.1%
biodegradation within 14 days) show that Glycerides, C8-10, mono- and
di- is not toxic to and therefore non-inhibitory of activated sludge
microorganisms activity.
The QSAR calculations were performed using the Ready biodegradability
model (version 1.0.8) of VegaNIC version 1.0.8. The model predicted
ready biodegradability for the main substance components (Birkhofer,
2015). All predictions are considered to be valid since the main
substance components are within the training set of the model. Based on
the weight of evidence approach Glyceryl undecylenate (CAS 123759-97-7)
is considered readily biodegradable.
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