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EC number: 206-117-5 | CAS number: 302-17-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of test material: 2,2,2-Trichloroethane-1,1-diol (Chloral hydrate)
- Molecular formula: C2-H3-Cl3-O2
- Molecular weight: 165.4026g/mol
- Smiles notation: C(C(O)O)(Cl)(Cl)Cl
- InChl: RNFNDJAIBTYOQL-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: Solid - Analytical monitoring:
- not specified
- Vehicle:
- no
- Details on test solutions:
- The test substance was soluble in water, therefore, the stock solution was prepared by dissolving 1 gm of the test substance in 1 liters of potable water (passed through reverse osmosis system then the Stock solution was used for achieving test concentrations of 6.25 mg/L, 12.5 mg/L, 25 mg/L, 50 mg/L & 100 mg/L, respectively.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Zebra Fish (Danio rerio)
Duration of housing: 15 days
Photoperiod: 12 hours light and 12 hours darkness
Oxygen content: 8.4 (mg/l)
pH: 8.4
Water temperature: 27.8 °C
Mortality (%): During last 14 days = 0 %
Diet: Standard brand feed, once daily - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 53.75 (mg of CaCO3)
- Test temperature:
- 27.8 °C
- pH:
- 7.1
- Dissolved oxygen:
- 8.4 (mg/l)
- Salinity:
- No data
- Nominal and measured concentrations:
- 6.25, 12.5, 25, 50 and 100 mg/L
- Details on test conditions:
- Photoperiod: 12 hours light and 12-hour darkness
Volume of water: 2 liters
No. of animals per vessel: 8 fishes
Test temperature: 23.7-24.7°C
Adaptation: Test conditions corresponded to housing conditions
Test dates: Test started at : 26/10/2015
Test item exposure at: 03/11/2015
Date of experimental termination: 07/11/2015
Withdrawal of food : 1 day before and during exposure
Aeration: Aeration in test vessels was provided 1 day before the start of experiment - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- A 96 h study was conducted for CAS No. 302-17-0 on Zebra fish (Denio rario), at a test concentrations of 6.25 mg/L, 25mg/L, 50mg/L, 100mg/L. The fishes were moving slowly as compared to control. No mortalities were found in the control aquaria.
LC0 (96 hours) (highest loading at which no mortality was observed) = 100 mg/L
LC50 (96 hours) Experimental = > 100 mg/L - Validity criteria fulfilled:
- yes
- Conclusions:
- Based on nominal concentrations, experimental median lethal Concentrations [LC-50 (96 h)] for CAS No. 302-17-0 on Zebra Fish (Denio rario) was found to be > 100 mg/L.
- Executive summary:
Fish Acute Toxicity test according to OECD Guideline 203 was conducted for 2,2,2-trichloroethane-1,1-diol. The nominal concentration selected for the experiment were 6.25 mg/L, 12.5mg/L,25mg/L, 50mg/L, 100mg/L and Zebra Fishes (Denio rario) were exposed to these concentration for 96 hours. The lethal concentrations i.e. LC50 value was determined to be > 100mg/L.
This value indicates that the substance 2,2,2-trichloroethane-1,1-diol (Chloral hydrate) is not toxic to fish and hence considered as Not classified as per CLP classification criteria.
Reference
Description of key information
Based on nominal concentrations, experimental median lethal Concentrations [LC-50 (96 h)] for CAS No. 302-17-0 on Zebra Fish (Denio rario) was found to be > 100 mg/L.
This value indicates that the substance 2,2,2-trichloroethane-1,1-diol (Chloral hydrate) is not toxic to fish and hence considered as Not classified as per CLP classification criteria.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Two different experimental studies were reviewed for short term toxicity to fish for the test substance 2,2,2-trichloroethane-1,1-diol (Chloral hydrate). The same is presented below as key and supporting studies:
In key study, Fish Acute Toxicity test according to OECD Guideline 203 was conducted for2,2,2-trichloroethane-1,1-diol. The nominal concentration selected for the experiment were 6.25 mg/L, 12.5mg/L,25mg/L, 50mg/L, 100mg/L and Zebra Fishes (Denio rario) were exposed to these concentration for 96 hours. The lethal concentrations i.e. LC50 value was determined to be > 100mg/L.
While in supporting study obtained from J-check database, the lethal concentration (LC50) value of Chloral hydrate in fish (Oryzias latipes) in a 96 hr study on mortality effect was found to be >96 mg/L. Therefore the LC50 may be considered greater than 100 mg/L for Chloral hydrate. Also this chemical has a harmonized classification that does not indicate the chemical to cause aquatic toxicity.
Hence considering the key study value and harmonized classification, the substance 2,2,2-trichloroethane-1,1-diol (Chloral hydrate) is concluded to be not toxic to fish and hence considered as Not classified as per CLP classification criteria.
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