Registration Dossier
Registration Dossier
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EC number: 211-443-6 | CAS number: 645-45-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer- reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs: Benzyl acetone
- Author:
- Moreno
- Year:
- 1 983
- Bibliographic source:
- Food and Chemical Toxicology, Volume 21, Issue 5, October 1983, Pages 647-649
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity of Benzylacetone in rats
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 4-phenylbutan-2-one
- EC Number:
- 219-847-4
- EC Name:
- 4-phenylbutan-2-one
- Cas Number:
- 2550-26-7
- Molecular formula:
- C10H12O
- IUPAC Name:
- 4-phenylbutan-2-one
- Details on test material:
- - Name of test material (as cited in study report):4-phenylbutan-2-one- Molecular formula (if other than submission substance):C10H12O - Molecular weight (if other than submission substance):148.204 g/mole - Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):4-phenylbutan-2-one- Molecular formula (if other than submission substance):C10H12O - Molecular weight (if other than submission substance):148.204 g/mole - Substance type:Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 3200 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 200 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 300 - 4 450
- Remarks on result:
- other: 50 % mortality observed.
- Mortality:
- 50 % mortality was observed in treated rats at 3200 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 3200 mg/kg bw (2300-4450) when rat were treated with Benzylacetone orally
- Executive summary:
In a acute oral toxicity study, rats were treated with Benzylacetone orally in the concentration of 3200 mg/kg bw orally. 50 % mortality was observed in treated rats at 3200 mg/kg bw. Therefore, LD50 was considered to be 3200 mg/kg bw (2300-4450) when rat were treated with Benzylacetone orally
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