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EC number: 200-665-9 | CAS number: 67-71-0
In a subchronic study, male and female Wistar [Crl:(WI)BR] rats (20/sex) were orally administered (via gavage) either distilled water or 1500 mg/kg/day of test substance in distilled water for 90 days. The major organs were weighed and fixed in formaldehyde for histopathological observations, and clinical chemistry parameters (i.e., serum enzymes, lipid profile,serum proteins, albumin and blood chemistries) and urinalysis parameters (i.e., appearance, volume, specific gravity, pH, protein, glucose, and blood) were analyzed. No effects on body weight, hematological parameters or histopathological lesions in organs and tissues were found. At necropsy, no gross pathological changes or differences in organ weights were noted, except for a significant increase in kidney weights of treated male rats. Histopathological examination of kidneys in both males and females did not reveal any treatment related lesions, and therefore the significant kidney weight difference was considered likely due to low within-group deviations rather than a toxicological effect. Thus, the no-observed adverse effect level (NOAEL) of test substance in this 90 day gavage study was determined to be 1500 mg/kg/day.
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