Registration Dossier

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets generally accepted scientific principles For read-across justification refer to section 13.

Data source

Reference
Reference Type:
publication
Title:
The Metabolism of 14C Labeled Ethylenediaminetetraacetic Acid in Human Beings
Author:
Foreman H et al.
Year:
1954
Bibliographic source:
J Lab Clin Med 43, 566-571

Materials and methods

Principles of method if other than guideline:
Details on study design: - 3 young healthy adult male were used in each application group
Endpoint addressed: basic toxicokinetics
Endpoint addressed: dermal absorption

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Conclusions:
CaNa2EDTA does not penetrate the skin.