Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-837-1 | CAS number: 111-13-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Experimental test result performed using standard OECD test guideline.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Principles of method if other than guideline:
- The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117.
- GLP compliance:
- not specified
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.956
- Temp.:
- 25 °C
- pH:
- 6.95
- Remarks on result:
- other: logKow was reported as 1.9565 ± 0.0013
- Details on results:
- The Partition coefficient (Pow) of the test chemical was determined to be 1.9565 ± 0.0013 at 25°C.
- Conclusions:
- The partition coefficient(n-octanol/water) of test chemical was determined as per the HPLC method (OECD Guideline- 117). The Log Pow value was determined to be 1.9565 ± 0.0013 at 25°C.
- Executive summary:
The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test item solution was prepared by accurately measuring 4μL of test item and diluted with methanol up to 10 ml. Thus, the test solution concentration was 327.6 mg/l. The pH of test substance was 6.95. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were having Pow value ranging from 1.0 to 4.6. The Log Pow value was determined to be 1.9565 ± 0.0013 at 25°C. Based on this value, it can be concluded that test chemical is hydrophilic in nature.
Reference
Test substance |
K |
LogK |
Log Pow by Generalized Calibration Graph |
Mean of logPow ± S.D |
|
Tr1 |
1.516 |
0.6869 |
-0.1631 |
1.9574 |
1.9565± 0.0013 |
Tr2 |
1.515 |
0.6858 |
-0.1638 |
1.9566 |
|
Description of key information
Based on the available data from study report,the partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test item solution was prepared by accurately measuring 4μL of test item and diluted with methanol up to 10 ml. Thus, the test solution concentration was 327.6 mg/l. The pH of test substance was 6.95. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were having Pow value ranging from 1.0 to 4.6. The Log Pow value was determined to be 1.9565 ± 0.0013 at 25°C. Based on this value, it can be concluded that test chemical is hydrophilic in nature.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.95
- at the temperature of:
- 25 °C
Additional information
Based on the available data from study report,the partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test item solution was prepared by accurately measuring 4μL of test item and diluted with methanol up to 10 ml. Thus, the test solution concentration was 327.6 mg/l. The pH of test substance was 6.95. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were having Pow value ranging from 1.0 to 4.6. The Log Pow value was determined to be 1.9565 ± 0.0013 at 25°C. Based on this value, it can be concluded that test chemical is hydrophilic in nature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
