Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Monograph on fragrance raw materials, METHYL HEXYL KETONE
Author:
Edited by D. L. J. Opdyke
Year:
1975
Bibliographic source:
Food and Cosmetics Toxicology Volume 13, Issue 6 pp 861, 1975
Reference Type:
review article or handbook
Title:
Investigation of selected potential of contaminants: Ketonic Solvents
Author:
Sheldon S Lande, Patrick R Durkin, Deborah H Christopher, Philip H Howard, Jitendra Saxena
Year:
2003
Bibliographic source:
EPA-560/2-76-003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
An acute inhalation study was carried out on guinea pigs to estimate the inhalation toxicity of ketonic vapors
GLP compliance:
no
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Octan-2-one
EC Number:
203-837-1
EC Name:
Octan-2-one
Cas Number:
111-13-7
Molecular formula:
C8H16O
IUPAC Name:
octan-2-one
Details on test material:
- Name of test material: 2-octanone
- IUPAC name: octan-2-one
- Molecular formula: C8H16O
- Molecular weight: 128.2134 g/mol
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material: 2-octanone
- IUPAC name: octan-2-one
- Molecular formula: C8H16O
- Molecular weight: 128.2134 g/mol
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
other: saturated atmosphere
Vehicle:
not specified
Details on inhalation exposure:
Guinea-pig was exposed to an essentially saturated atmosphere (1300 ppm)
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
14 h
Concentrations:
1300 mg/L
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
Details on study design
Duration of observation period following administration: 14 days (or other?): clinical signs, behavioral changes were examined.
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levelsopen allclose all
Key result
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 1 300 mg/L air
Based on:
test mat.
Exp. duration:
14 h
Remarks on result:
other: no other details specified
Key result
Sex:
not specified
Dose descriptor:
LC0
Effect level:
1 300 mg/L air
Based on:
test mat.
Exp. duration:
14 h
Remarks on result:
other: No mortality observed
Mortality:
No mortality was observed in treated guinea pig till 1300 mg/L, LC50 was considered as > 1300 mg/L
Clinical signs:
other: Nasal irritation developed immediately after the guinea-pig was exposed to an essentially saturated atmosphere (1300 mg/lt) This was followed by muscular weakness after exposure for approximately 10 hr and by coma after approximately 12 hr
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
As no mortality was observed in treated guinea pig till 1300 mg/L of exposed test chemical for 14 hrs, the acute inhalation LC50 was considered as > 1300 mg/L (i.e. 1300000 mg/m3).
Executive summary:

In a acute inhalation toxicity study, guinea pig were exposed with test chemical in the concentration of 1300 mg/L in saturated atmosphere for 14 hours. No mortality was observed in treated guinea pig at 1300 mg/L and Nasal irritation developed immediately after the guinea-pig was exposed to an essentially saturated atmosphere (1300 mg/lt). This was followed by muscular weakness after exposure for approximately 10 hr and by coma after approximately 12 hr. As no mortality was observed in treated guinea pig till 1300 mg/L of exposed test chemical, acute inhalation LC50 was considered as > 1300 mg/L.