Registration Dossier
Registration Dossier
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EC number: 233-059-8 | CAS number: 10026-12-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 96-h acute toxicity of niobium pentachloride in fish was tested in a GLP study according to OECD Guideline 203. A limit test applying a loading rate of 100 mg/L of the test substance did not lead to mortality. No further study was carried out.
Key value for chemical safety assessment
Additional information
In the course of a 96-h limit test according to OECD Guideline 203 (July 1992) and under GLP, Danio rerio was exposed to niobium pentachloride at nominal loading rates of 0 (control) and 100 mg/L under semi-static conditions. No mortality was observed. Therefore, no further testing was carried out. The analytically measured niobium concentration in solution showed high variability and ranged from 101 to 2.2 µg/L. This was mainly due to the fact that small changes in pH caused significant changes in the soluble fraction of the test substance. Additionally, niobium pentachloride precipitated after adjusting the pH. Furthermore, agglomeration reactions and effects of adsorption to vials and analytical instruments contributed to the varying measured niobium concentrations in solution. Therefore, effect levels are given as nominal loading rates and mean measured concentrations of niobium. The chemical analysis revealed a geometric mean of 11.88 µg/L (measured) of the test substance in the test media. Hence, the 96-h LL50 (nominal) is > 100 mg/L, and the LC50 (geometric mean of measured concentrations) is > 11.88 µg/L. This study is classified as acceptable and satisfies the guideline requirement for a fish acute toxicity study.
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