Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-118-3 | CAS number: 12070-06-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In vitro bioavailability studies in simulated body fluids were conducted with the target substance tantalum carbide. Only in the artificial interstitial body fluid the release of tantalum was above the detection limit of the method, namely 0.005%.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
The bioaccessibility of tantalum carbide as a surrogate for bioavailability was measured. For this purpose soluble tantalum ions were measured using the EPA method #200.8 (ICP/MS) after incubation of tantalum carbide in different simulated body fluids (simulated gastric fluid, simulated interstitial fluid, simulated lysosomal fluid and artificial perspiration).
In summary, in all body fluids the release of tantalum ions was below the detection limit of the methodology used, except for the simulated lysosomal body fluid, in which the release of tantalum was measured with 0.005%. Based on the results, the bioavailability of tantalum carbide can be considered to be very low for all routes of administration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
