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EC number: 202-870-9 | CAS number: 100-61-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
N-methylaniline has got a not negligible acute toxicity: oral LD50 rabbit is 280 mg/kg/bw, dermal LD100 ≥ 3000 mg/kg/bw but no data for inhalator acute toxicity are available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 280 mg/kg bw
- Quality of whole database:
- SCOEL/SUM/178 of December 2012 for N-methylaniline
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Quality of whole database:
- In SCOEL/SUM/178 of December 2012 for N-methylaniline with reference to Treon et all, J Ind Hyg Toxicol 31:1-20, 1949 LD100≥ 3000 mg/kg/ is reported. This value is of concern but insufficient for classification.
Additional information
Oral exposure:
As reported in SCOEL/SUM/178 of December 2012 for N-methylaniline with reference to NISH Japan 2010 after oral administration by gavage (in corn oil) to rats, LD50 between 700 and 800 mg/kg bw were determined following current OECD guidelines. The minimum lethal dose in this study was 640 mg/kg for both sexes. In an older study (see Treon et all, J Ind Hyg Toxicol 31:1-20, 1949) the minimum lethal oral dose of N-methylaniline for rabbits was 280 mg/kg. Following the precautionary approach, the lowest LD50 (280 mg/kg) must be used for the risk assessment.
N-methylaniline is included in annex VI of CLP Regulation (EC n. 1272/2008) and it is classified H301 (acute oral toxicity cat.3).
Inhalation exposure:
As reported in SCOEL/SUM/178 of December 2012 for N-methylaniline data on the inhalation toxicity of NMA after a single exposure were not available.
However, N-methylaniline is included in annex VI of CLP Regulation (EC n. 1272/2008) and it is classified H311 (acute inhalator toxicity cat.3)
Dermal exposure:
As reported in SCOEL/SUM/178 of December 2012 for N-methylaniline with reference to Treon et all, J Ind Hyg Toxicol 31:1-20, 1949 cyanosis and death were observed in all rabbits after dermal application on the intact skin of ≥ 3 000 mg/kg for 1 hour or longer. It is not possible to classified the substance according CLP using this data. According to CLP Regulation (EC n. 1272/2008) for the classification the value LD50 ≤ 2000 mg/kg/bw is required.
However, N-methylaniline is included in annex VI of CLP Regulation (EC n. 1272/2008) and it is classified H331 (acute dermal toxicity cat.3).
Justification for selection of acute toxicity – oral endpoint
Data from reliable source (Scientific Commitee on Occupational Exposure Limit SCOEL)
Justification for selection of acute toxicity – dermal endpoint
In the study Treon et all, J Ind Hyg Toxicol 31:1-20, 1949 is reported only LD100
Justification for classification or non-classification
N-methylaniline has got a not negligible acute toxicity: ral LD50 rabbit is 280 mg/kg/bw, dermal LD100 ≥3000 mg/kg/bw but no data for inhalator acute toxicity are available.
Regarding acute dermal toxicity, LD100 = 3000 mg/kg/bw is not sufficient for classification accrding to CLP Regulation (EC n. 1272/2008). However, N-methylaniline is included in annex VI of CLP Regulation (EC n. 1272/2008) and it is classified H301 (acute oral toxicity cat.3), H311 ( acute inhalator toxicity cat.3) and H331 (acute dermal toxicity cat.3).
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