Registration Dossier
Registration Dossier
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EC number: 211-219-8 | CAS number: 634-93-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of test chemical was performed in rodents.
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2018
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity study of test chemical was performed in rodents.
- Author:
- Richard J. Lewis
- Year:
- 2 012
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set,2012
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of test chemical was performed in rodents.
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US national Library of Medicine,2018
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study of test chemical was performed in rodents.
- Author:
- RTECS
- Year:
- 2 018
- Bibliographic source:
- RTECS (registry of toxic effect of chemical substance database), 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of test chemical was performed in rodents.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2,4,6-trichloroaniline
- EC Number:
- 211-219-8
- EC Name:
- 2,4,6-trichloroaniline
- Cas Number:
- 634-93-5
- Molecular formula:
- C6H4Cl3N
- IUPAC Name:
- 2,4,6-trichloroaniline
- Details on test material:
- - Name of test material: 2,4,6-trichloroaniline
- Molecular formula : C6H4Cl3N
- Molecular weight : 196.464 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 2,4,6-trichloroaniline
- Molecular formula : C6H4Cl3N
- Molecular weight : 196.464 g/mol
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 1180 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- Details on study design:
- Other examinations performed: clinical signs - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 180 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at dose 1180 mg/kg bw
- Clinical signs:
- other: In Clinical signs observations, behavioral changes in motor activity (specific assay); convulsions or effect on seizure threshold;Somnolence (general depressed activity) were seen.
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be 1180 mg/kg bw,when mouse were treated with 2,4,6-trichloroaniline (634-93-5) orally.
- Executive summary:
Acute oral toxicity study was performed in mouse using test chemical.50% mortality was observed at dose 1180 mg/kg bw. Hence,LD50 value was considered to be 1180 mg/kg bw,when mouse were treated with 2,4,6-trichloroaniline (634-93-5)orally.
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