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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from Authoritative database

Data source

Referenceopen allclose all

Reference Type:
other: Authoritative database
Title:
Acute dermal toxicity study of test chemical was performed in rodents.
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2018
Reference Type:
other: Authoritative database
Title:
Acute dermal toxicity study of test chemical was performed in rodents.
Author:
IFA GESTIS
Year:
2018
Bibliographic source:
Gestis Substance Database ,2018
Reference Type:
review article or handbook
Title:
Acute dermal toxicity study of test chemical was performed in rodents.
Author:
Food & Agriculture Org.
Year:
1999
Bibliographic source:
Pesticide Residues in Food, Pg. 76,1999
Reference Type:
review article or handbook
Title:
Acute dermal toxicity study of test chemical was performed in rodents.
Author:
S. Gangolli
Year:
1999
Bibliographic source:
The Dictionary of Substances and Their Effects: E-J,D260, 1999
Reference Type:
secondary source
Title:
Acute dermal toxicity study of test chemical was performed in rodents.
Author:
RTECS
Year:
2018
Bibliographic source:
RTECS (registry of toxic effect of chemical substance database), 2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute dermal toxicity study of test chemical was performed in rodents.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6-dichloro-4-nitroaniline
EC Number:
202-746-4
EC Name:
2,6-dichloro-4-nitroaniline
Cas Number:
99-30-9
Molecular formula:
C6H4Cl2N2O2
IUPAC Name:
2,6-dichloro-4-nitroaniline
Details on test material:
- Name of test material (IUPAC name): 2,6-dichloro-4-nitroaniline
- Common name: Dicloran
- Molecular formula: C6H4Cl2N2O2
- Molecular weight: 207.016 g/mol
- Smiles notation: c1(cc(c(N)c(c1)Cl)Cl)[N+](=O)[O-]
- InChl: 1S/C6H4Cl2N2O2/c7-4-1-3(10(11)12)2-5(8)6(4)9/h1-2H,9H2
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (IUPAC name): 2,6-dichloro-4-nitroaniline
- Common name: Dicloran
- Molecular formula: C6H4Cl2N2O2
- Molecular weight: 207.016 g/mol
- Smiles notation: c1(cc(c(N)c(c1)Cl)Cl)[N+](=O)[O-]
- InChl: 1S/C6H4Cl2N2O2/c7-4-1-3(10(11)12)2-5(8)6(4)9/h1-2H,9H2
- Substance type: Organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Type of coverage:
other: dermal
Vehicle:
not specified
Details on dermal exposure:
No data
Duration of exposure:
No data
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Preliminary study:
No data
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed at dose 2000 mg/kg bw
Clinical signs:
other: No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
The LD50 value was considered to be >2000 mg/kg bw,when rabbits were treated with test chemical by dermal application.
Executive summary:

In acute dermal toxicity study, rabbits were treated with test chemical in the concentration of 2000 mg/kg bw by dermal application.No mortality was observed in treated rabbits at dose 2000 mg/kg bw.Therefore, LD50 value was considered to be >2000 mg/kg bw,when rabbits were treated with test chemical by dermal application.