Registration Dossier
Registration Dossier
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EC number: 943-007-2 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on fish up to the limit of water solubility
Key value for chemical safety assessment
Additional information
Data on the acute toxicity of the target substance Fatty acids, C12-18, even numbered, 3-methylbutyl esters (CAS 1314763-50-2) to fish is not available. The assessment was therefore based on studies conducted with the analogue substances Isopropyl myristate (CAS 110-27-0) and Isopropyl palmitate (CAS 142-91-6) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification section 13.
The toxicity of the source substance Isopropyl myristate (CAS 110-27-0) to bluegill (Lepomis macrochirus) was tested according to EPA Guideline EPA 660/3-75-009 (Sousa et al. 1979). The static test was set up with the nominal test concentrations 78, 130, 220, 360, 600 and 1000 mg/L. There were no toxic effects observed in the species tested after an incubation period of 96 h up to 1000 mg/L, resulting in an LC50 (96 h) value of >1000 mg/L. After 24 and 48 h fish were observed to behave lethargic, however all fish recovered. Chemical flakes were observed to adhere to the glassware and tubes and/or collect as film at the surface. In a second study the acute toxicity of the source substance Isopropyl palmitate (CAS 142-91-6) to the zebra fish (Danio rerio) was tested under semi-static conditions according to ISO 7346 -1 at the following concentrations: 1000, 3000 and 10000 mg/L (Richterich, 2001). There were no toxic or sublethal effects observed in the species tested after an incubation period of 96 h at any concentration (LC50 (96 h) > 10000 mg/L).
Based on the results for the read-across substances, Fatty acids, C12-18, even numbered, 3-methylbutyl esters (CAS 1314763-50-2) is considered to be not toxic to fish within the limit of water solubility.
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