Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 695-949-6 | CAS number: 1187576-41-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC10 > 1000 mg/L (nominal) for respiration inhibition of activated sludge or P. putida, read across
Key value for chemical safety assessment
Additional information
Since no study for assessing the toxicity to aquatic microorganisms of 2-Butenedioic acid (2E)-, di-C14-16-alkyl esters (List No 695-949-6) is available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category members 2-Butenedioic acid (E)-, didodecyl ester (CAS 2402-58-6, MW 453 g/mol), 2-Butenedioic acid (E)-, ditetradecyl ester (CAS 10341-03-4, MW 509 g/mol) and 2-Butenedioic acid (E)-, di-C18-22-alkyl esters (CAS 68921-53-9, MW 621-733 g/mol) was conducted. 2-Butenedioic acid (2E)-, di-C14-16-alkyl esters (List No 695-949-6) exhibits a molecular weight range of 508.82 – 564.92 g/mol. Thus, the read across is covered by interpolation for this substance. The read across is justified due to a) the structural similarity of the category members and b) similar physico-chemical properties resulting in a similar environmental fate and ecotoxicity profile.
Further justification is given in the endpoint summary 6.1 and within the category justification in section 13.
Activated sludge respiration inhibition tests conducted according to OECD 209 are available for the PFAE fumarates category members 2-Butenedioic acid (E)-, ditetradecyl ester (CAS 10341-03-4) and 2-Butenedioic acid (E)-, di-C18-22-alkyl esters (CAS 68921-53-9). No effects were observed in concentrations well above the limit of water solubility. In addition, an oxygen consumption test according to a German national guideline (DIN 38412, part 27) is available for 2-Butenedioic acid (E)-, didodecyl ester (CAS 2402-58-6), showing no effects on Pseudomonas putida as well (Kirch, 1995).
The results of all three studies show distinctly, that no effects occur in the range of water solubility and well above the water solubility (i.e. EC10 > 1000 mg/L in all tests). Therefore, disturbances in sewage treatment plants are not anticipated for the members of the PFAE fumarates category.
Due to the structural and physico-chemical property similarities with the tested category members 2-Butenedioic acid (E)-, didodecyl ester (CAS 2402-58-6), 2-Butenedioic acid (E)-, ditetradecyl ester (CAS 10341-03-4) and 2-Butenedioic acid (E)-, di-C18-22-alkyl esters (CAS 68921-53-9), this result is also applicable to read across to 2-Butenedioic acid (2E)-, di-C14-16-alkyl esters (List No 695-949-6).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
