Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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First-aid measures

The following first aid measures are recommended :

Eyes : Begin immediate eye irrigation with cool water for at least 15 minutes with the eyelids held open by gently separating them with the fingers. Get immediate medical attention promptly.

Skin : Immediately flush with large amounts of water. Remove contaminated clothing, including shoes, and wash with soap and water. Get medical attention.

Metal alkyls and solutions of metal alkyls react with air and with body moisture. Immediate flushing with large volumes of water will kill residual alkyl, carry away the heat of reaction, and cool burned tissue. Such burns will be predominately thermal and should be treated medically as such. Immediate application of cold water has been found to reduce the severity of burns. For treatment of injury or shock, the services of a physician are required.

Inhalation of vapours from metal alkyl and solutions of metal alkyl fires or decomposition may cause immediate irritation of the respiratory tract. Excessive or prolonged inhalation of vapours may cause "metal fume fever". Symptoms are throat irritation, headache, fever, chills, nausea, constricting sensation of the lungs. If signs or symptoms occur, remove to fresh air. If breathing stops, apply articificial respiration, preferably by mouth-to-mouth. Give oxygen if needed. Get medical attention.

Protective equipment should be determined by the degree of possible exposure. Eye protection should include goggles or face shields for even minimal exposure. Exposure to large quantities, as in plant transfers, requires a full body aluminised proximity suit.
Gloves used in plant transfers or operations should be aluminised leather, preformed neoprene, aluminised vinyl or other fire resistant, nonreactive material.
Preformed rubber gloves may be used in the laboratory. All gloves used when handling metal alkyls and solutions of metal alkyls should be loose-fitting for instant removal if necessary.

Spills of metal alkyl solutions may or may not spontaneously ignite depending upon conditions surrounding the spill. However, the flash point of the solution is considerably below the flash point of the solvent, and the flash point for solutions should be considered as less than -48°C. Additional precautions normally observed when handling the solvent should be followed when using solutions of metal alkyls. Breathing of solvent vapours may cause headache, dizziness, nausea, vomiting and loss of consciousness. If signs or symptoms occur from breathing vapours, remove to fresh air. If breathing stops, apply artificial respiration, preferably mouth-to-mouth. Give oxygen, if needed. Get medical attention. If pure solvent is swallowed, give a minimum of two glasses (500 ml) of water.
Do NOT induce vomiting. Get immediate medical attention.

Fire-fighting measures

The following general procedures are recommended for fires involving metal alkyls:

No standard methods have been developed for extinguishing large-scale metal alkyl fires. Small fires may be extinguished using carbon dioxide, dry powder, or dry sand provided that a large excess of the extinguishing material is used. Water based foams, chemical foams, and halogenated extinguishers should NOT be used.

The following procedure is recommended for handling metal alkyls when there are fires in the vicinity :

If a container is threatened by fire from an external source (not from the chemical itself), extinguish the external fire by conventional means, or move the container, whichever can be done quicker and with less danger. If this cannot be done, keep container cool by spraying water on it. Water reacts violently with metal alkyls but has been found to be an effective fire control treatment if one is thoroughly familiar with the violent reaction and personnel are properly protected from explosion.

Accidental release measures

The following general procedures are recommended for spills or leaks involving portable containers of metal alkyls:

a. Water may be used (only if one is thoroughly familiar with the violent reaction and if personnel are properly protected from possible explosion) to decompose metal alkyls from small leaks and to keep adjacent tanks or equipment cool.

b. If leaking liquid from a container is burning, move flammables away or move the container to a safe place, if possible. Avoid increasing the leak. Keep water, materials wet with water, and liquid fire extinguishers away. Small leak fires can be controlled with dry materials or with water, if one is thoroughly familiar with the violent reaction and if personnel are properly protected from possible explosion. If possible, use sandbags to contain and isolate the burning liquid. The use of a remote control vaporisation system can be considered, particularly in the case of a limited leak which cannot be stopped. The water spray permits the agent to be burnt as soon as it appears, the heat from the reaction with the water and air to be absorbed, the combustion chamber and the adjacent equipment to be cooled off, the radiating heat to be decreased, and the gases emitted to be absorbed.

c. If gases leaking from the vapour space of a container are burning, proceed also as in item b). In this instance, the fire will very likely extinguish itself as the container vapour space pressure declines to atmospheric.

d. If liquid is leaking from a container but is not burning, ventilate the area or move the container out in the open, otherwise, proceed as in item b).

Handling and storage

Metal Alkyls are highly reactive compounds. Most commercially available Metal Alkyls react explosively with water with the concurrent release of extremely flammable gases, and they are pyrophoric, i.e. they ignite spontaneously on contact with air. The hazardous properties of Metal Alkyls make it necessary to take all precautions necessary to avoid accidental spillage.

Consequently, handling of these compounds requires rigorous exclusion of air and moisture. The products are transported under a nitrogen blanket in specially designed portable tanks. Transfer of the product from the production facilities into these portable tanks, and from the tanks to the customers facilities, takes place using closed systems in dedicated unloading stations.

Due to their pyrophoric and water-reactive nature,
(a) Metal Alkyls are rigorously contained by technical means during their whole lifecycle, including manufacture, purification, cleaning and maintenance of equipment, sampling, analysis, loading and unloading of equipment or vessels, waste disposal and storage;
(b) Procedural and control technologies are in place that minimise emission and any resulting exposure
(c) Only properly trained and authorised personnel are handling Metal Alkyls;
(d) In the case of cleaning and maintenance works, special procedures such as purging and washing are applied before the system is opened and entered
(e) In cases of accident and where waste is generated, procedural and/or control technologies are used to minimise emissions and the resulting exposure during decontamination or cleaning and maintenance procedures;
(f) Substance-handling procedures are well documented and strictly supervised by the site operator.

For aluminium alkyls such as EASC, any contact with air - even for very small amounts - will be indicated by generation of smoke or spontaneous ignition. Therefore they are stored and handled in hermetically closed systems under inert gas like nitrogen or argon.

Connecting and disconnecting procedures of transport containers must be in place, along with procedures for breaking and reconnecting lines and reactors.

Transport information

Land transport (ADR/RID)

UN number:
3394
Proper shipping name and description:
Organometallic subtance, liquid, pyrophoric, water-reactive (Ethylaluminium sesquichloride)
UN 3394 Organometallic substance, liquid, pyrophoric, water-reactive (Ethylaluminium sesquichloride), 4.2 (4.3), I
Chemical name:
Triethyldialuminium trichloride
Language:
English
Class:
4.2 (4.3)
Classification code:
SW
Packaging group:
I
Labels:
4.2 + 4.3
Remarks:
Uncleaned empty packagings/transport equipments, ROAD (ADR/RID):

Empty packaging, tank-trailer, tank-container, portable tank,..., uncleaned residue last contained UN 3394 Organometallic substance, liquid, pyrophoric, water-reactive (Ethylaluminium sesquichloride), 4.2 (4.3), I

Inland waterway transport (ADN(R))

UN number:
3394
Proper shipping name and description:
Organometallic subtance, liquid, pyrophoric, water-reactive (Ethylaluminium sesquichloride)
UN 3394 Organometallic substance, liquid, pyrophoric, water-reactive (Ethylaluminium sesquichloride), 4.2 (4.3), I
Chemical name:
Triethyldialuminium trichloride
Language:
English
Class:
4.2
Classification code:
SW
Packaging group:
I
Labels:
4.2 + 4.3
Remarks
Uncleaned empty packagings/transport equipments, ):

Empty packaging, tank-trailer, tank-container, portable tank,..., uncleaned residue last contained UN 3394 Organometallic substance, liquid, pyrophoric, water-reactive (Ethylaluminium sesquichloride), 4.2 (4.3), I

Marine transport (IMDG)

UN number:
3394
Proper shipping name and description:
Organometallic subtance, liquid, pyrophoric, water-reactive (Ethylaluminium sesquichloride)
UN 3394 Organometallic substance, liquid, pyrophoric, water-reactive (Ethylaluminium sesquichloride), 4.2 (4.3), I
Chemical name:
Triethyldialuminium trichloride
Class:
4.2
Packaging group:
I
EmS code:
F-G, S-M
Labels:
4.2 + 4.3
Remarks
Uncleaned empty packagings/transport equipments, ):

Empty packaging, tank-trailer, tank-container, portable tank,..., uncleaned residue last contained UN 3394 Organometallic substance, liquid, pyrophoric, water-reactive (Ethylaluminium sesquichloride), 4.2 (4.3), I

Air transport ICAO/IATA

UN number:
3394
Proper shipping name and description:
Forbidden

Organometallic substance, liquid, pyrophoric, water-reactive (Ethylaluminium sesquichloride)
UN 3394 Organometallic substance, liquid, pyrophoric, water-reactive (Ethylaluminium sesquichloride), 4.2 (4.3), I
Chemical name:
Triethyldialuminium trichloride
Class:
4.2
Packaging group:
I
Labels:
4.2 + 4.3
Remarks
Air transportation is forbidden.
SpecialProvisionsopen allclose all

Exposure controls / personal protection

Skin protection :
Use full aluminised safety suit when transferring material (large scale) and whenever contact may occur.

Eye protection :
Chemical goggles and the aluminised hood of a safety suit. Goggles and face shield for small scale laboratory operation.

Hands protection :
Use loose fitting aluminized or leather gloves.

Respiratory protection :
Dust, fume, and acid gas respirator when working in irritating fumes from decomposition. Supplied air respirator if working in a confined area.

Strictly Controlled Conditions:
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.

Written confirmation of application of Strictly Controlled Conditions has been received from every affected Distributor and Downstream Manufacturer/User of the Registrant's intermediate.

Stability and reactivity

EASC ignites upon exposure to air and reacts violently with water. Hydrocarbon solutions fo EASC may also ignite upon exposure to air.

Disposal considerations

The first step is to minimise waste generation.
The second step is to safely treat waste liquids on-site in accordance with environmental regulations, or to properly dispose of the waste using a licensed waste disposer. The general recommendation is to absorb and incinerate.