Reaction mass of 2-[[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]methyl]oxirane and 1,3-bis[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]propan-2-ol and 1-[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]-3-[4-[[4-[3-[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]-2-hydroxy-propoxy]-3,5-dimethyl-phenyl]methyl]-2,6-dimethyl-phenoxy]propan-2-ol

Ecotoxicological Summary

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:

PNEC aqua (freshwater)

PNEC value:

4 µg/L

Assessment factor:

50

Extrapolation method:

assessment factor

PNEC freshwater (intermittent releases):

20.21 µg/L

Marine water

Hazard assessment conclusion:

PNEC aqua (marine water)

PNEC value:

0.4 µg/L

Assessment factor:

500

Extrapolation method:

assessment factor

STP

Hazard assessment conclusion:

PNEC STP

PNEC value:

100 mg/L

Assessment factor:

10

Extrapolation method:

assessment factor

Sediment (freshwater)

Hazard assessment conclusion:

PNEC sediment (freshwater)

PNEC value:

0.017 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:

PNEC sediment (marine water)

PNEC value:

0.002 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:

no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:

PNEC soil

PNEC value:

0.001 mg/kg soil dw

Extrapolation method:

equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:

PNEC oral

PNEC value:

20 mg/kg food

Assessment factor:

300

Additional information

Short-term toxicity of the test substance to freshwater fish, invertebrates and algae have been determined experimentally. Aquatic invertebrates (Daphnia magna) immobilisation proved to be the most sensitive indicator of toxicity. Accordingly, a chronic Daphnia magna reproduction study was conducted which provided a NOELR value for reproduction/mortality which was used as a critical indicator for calculation of PNEC values for aquatic organisms.

The PNEC for STP microbes was calculated from an activated sludge respiration inhibition test (ASRIT) in activated sludge. No studies are available to assess the toxicity to sediment or terrestrial species. As such, the relevant sediment and soil PNEC values have been calculated using the equilibrium partitioning method using the Koc value for the major chromatographic component in the OECD 121 test (using a default non-hydrophobics QSAR class). It is acknowledged that as some components provided values in the test higher than the relevant standard (greater than 5.6), that a more specific PNEC for sediment and terrestrial effects could not be derived. As the relevant PNEC values have been calculated based on the major chromatographic component in the test, this is considered to be more representative of the test substance.

Conclusion on classification

No toxicity was observed to fish or algae up to the limit of aqueous solubility of the test material. For aquatic invertebrates (algae) an EC50 value of 2.021 mg/L was determined by statistical expolation. This value is considered the worst case value for toxicity to aquatic organisms, and as such no classification under the CLP regulation for acute aquatic toxicity is warranted. A chronic Daphnia reproduction study is available, which provides a NOELR of 0.2 mg/L. Based on this value, the lack of ready biodegradability and the lack of acute effects seen in fish and algae up to the solubility limit, this substance is considered to be classified under the CLP regulation as toxic to aquatic life with long lasting effects (Aquatic Chronic 2: H411).