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Reaction mass of 2-[[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]methyl]oxirane and 1,3-bis[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]propan-2-ol and 1-[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]-3-[4-[[4-[3-[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]-2-hydroxy-propoxy]-3,5-dimethyl-phenyl]methyl]-2,6-dimethyl-phenoxy]propan-2-ol
EC number: 941-357-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 797.1300 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- The test substance was added without a carrier solvent to dilution medium at the highest treatment level. This was then stirred for up to 4 hours, and the remaining concentrations prepared by serial dilution. The reported solubility of the test substance was incorrectly stated as 46.13 mg/L.
A reliable water solubility test has shown this to be much lower (1.26 mg/L). - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Source: Original source organisms from Aquatic Biosystems in Fort Collins, CO (Annual taxinomic verification provided).
- Age at study initiation: < 24 hours old (released within 8 hours of each other). - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- Moderately hard re-constituted water with a hardness value of 98 mg/L as CaCO3
- Test temperature:
- 20°C +/- 2°C
- pH:
- Dilution medium pH value of 8.1
- Dissolved oxygen:
- Dilution medium DO value of 7.9 mg/L
- Nominal and measured concentrations:
- Definitive phase: 0 (control), 2.83, 5.67, 11.25, 22.5 and 45 mg/L.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 35 mL Nalgene cups
- Type: open
- Material, size, headspace, fill volume: 25 mL (fill volume)
- Aeration: No data
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Moderately hard re-constituted water formulated from deionised water produced from E-Pure deionization system that is amended with reagent grade chemicals following EPA's Acute Whole Effluent Toxicity Test Methods.
- Total organic carbon: < 1.0 mg/L
- Chlorine: < 0.01 mg/L
- Alkalinity: 72 mg/L as CaCO3
- Conductivity: 341 umhos/cm
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light, 8 hours darkness
- Light intensity: 10-20 μE/m2/s (50-100 ft-c).
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Significant mortality at 24 and 48 hours
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: 0, 0.01, 0.1, 1, 10 and 100 mg/L
- Results used to determine the conditions for the definitive study - Reference substance (positive control):
- yes
- Remarks:
- Sodium Chloride
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2.021 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: based on statistical expolation
- Details on results:
- As the test substance is the major component of the registered substance, which being the most bioavailable; the bioavailability of this component within the registered substance can be expected to be reduced as it is chemically bound to dimers, trimers and oligomers. Based on statistical expolation of the results, EC50 was determined to be 2.021 mg/l. It was stated in the report that this value is lower than the limit of solubility which was 46.13 mg/l therefore showing toxicity at concentration less than the solubility of the test material. However, this value exceeded the limit of water solubility determine for this substance (1.26 mg/l) and therefore it is expected that the registered substance to be within this range.
Observation of the test solutions indicated that the substance was not fully dissolved and therefore may have led the Daphnia being exposed to concentration lower than the true limit of water solubility of this substance so this result need to be treated with caution. - Results with reference substance (positive control):
- - Results with reference substance within acceptable laboratory range
- EC50: 4.889 g/mL - Reported statistics and error estimates:
- A linear interpolation method was used to calculate the point estimates. Statistical analysis conducted using Steel Many-One rank Test at 24 and 48 hours.
- Validity criteria fulfilled:
- yes
- Remarks:
- No control mortality observed.
- Conclusions:
- In a 48 hr acute toxicity study, the 48hr EC50 value was determined 2.021 mg/L by statistical expolation.
Reference
Description of key information
In a 48hr acute toxicity study, Daphnia magna were exposed to the test substance at measured concentrations of 0 (control), 2.83, 5.67, 11.25, 22.5 and 45 mg/L (nominal) under semi-static conditions.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.021 mg/L
Additional information
As the test substance is the major component of the registered substance, which being the most bioavailable; the bioavailability of this component within the registered substance can be expected to be reduced as it is chemically bound to dimers, trimers and oligomers. Based on statistical expolation of the results, the EC50 was determined to be 2.021 mg/l. It was stated in the report that this value is lower than the limit of solubility which was 46.13 mg/l therefore showing toxicity at concentration less than the solubility of the test material. However, this value exceeded the limit of water solubility determine for this substance (1.26 mg/L) and therefore it is expected that the registered substance to be within this range.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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