Registration Dossier

Administrative data

Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1997
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Comparable to OECD Guideline study result, limited documentation

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1997

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
HET-CAM TEST (Hens Egg Test at the Chorion Allantois Membrane)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1,1,3-Trichloraceton
- Physical state: liquid
- Analytical purity: 85%
- Impurities (identity and concentrations): not mentioned

Test system

Vehicle:
other: DMSO
Controls:
yes, concurrent vehicle
Amount / concentration applied:
1, 10, 100 mg/l
Duration of treatment / exposure:
60 minutes
Observation period (in vivo):
immediately after exposure
Number of animals or in vitro replicates:
3 eggs
Details on study design:
HET-CAM TEST (Hens Egg Test at the Chorion Allantois Membrane)

Results and discussion

In vivo

Results
Irritation parameter:
other: HET CAM
Irritant / corrosive response data:
not reported
Other effects:
not reported

Any other information on results incl. tables

Substance is irritating to eys down to a concentration of 10 mg/l.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: other: HET-CAM TEST (Hens Egg Test at the Chorion Allantois Membrane)
Conclusions:
Substance is irritating to eyes down to concentrations of 10 mg/l
Executive summary:

A modified HET-CAM TEST (Hens Egg Test at the Chorion Allantois Membrane) has been used to investigate the mucous membrane irritating effects. 1,1,3 -Trichloroacetone showed irritating effects (not quantified in the literature) dowbn to 10 mg/l.