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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
before August 1987
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: comparable to OECD Guidelines, some details lacking

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1,3-trichloroacetone
EC Number:
213-063-6
EC Name:
1,1,3-trichloroacetone
Cas Number:
921-03-9
Molecular formula:
C3H3Cl3O
IUPAC Name:
1,1,3-trichloropropan-2-one
Details on test material:
- Name of test material (as cited in study report): 1,1,3-Trichloroacetone (1,1,3-TCA)
- Substance type: chemical
- Physical state: not reported
- Analytical purity: not reported

Test animals

Species:
mouse
Strain:
B6C3F1
Sex:
male/female
Details on test animals or test system and environmental conditions:
not given in report

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Emulphor EL-620
Details on oral exposure:
not given
Doses:
not given in report
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
Test was performed as a dose range finder for the in vivo micronucleus test.
Statistics:
not stated in report

Results and discussion

Preliminary study:
not available
Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
35 mg/kg bw
95% CL:
19 - 59
Sex:
female
Dose descriptor:
LD50
Effect level:
26 mg/kg bw
95% CL:
10 - 45
Mortality:
not reported
Clinical signs:
other: not reported
Gross pathology:
not reported
Other findings:
not reported

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Substance is toxic via oral application under the conditions used.
Executive summary:

In an oral acute toxicity test used as a dose range finder for a micronucleus assay in vivo, the test item turned out to have a LD 50 for mice of 35 mg/kg bw for males and 26 mg/kg bw for females.